You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SEC24B
Protein transport protein Sec24B

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265175
  • ENSP00000265175
  • ENSG00000138802
  • ENST00000399100
  • ENSP00000382051
  • ENST00000504968
  • ENSP00000428564

Symbol
  • SEC24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
protein domain
0.92
interacting protein
0.91
transcription factor binding site profile
0.81
biological process
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.32   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.32   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (271)
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.999800348
p_ni:  0.000199652
Score:  0.992
Data Source:  BioPlex,STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
p_int:  0.985334924
p_ni:  0.014665076
Data Source:  BioPlex
C8G
Tbio
Novelty:  0.02322575
p_int:  0.944426376
p_ni:  0.055573624
Score:  0.282
Data Source:  BioPlex,STRINGDB
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.938225034
p_ni:  0.061774966
Data Source:  BioPlex
MRM3
Tbio
Family:  Enzyme
Novelty:  0.06515109
p_int:  0.933463313
p_ni:  0.066536687
Score:  0.194
Data Source:  BioPlex,STRINGDB
HHIPL1
Tdark
Novelty:  0.57780473
p_int:  0.897289101
p_ni:  0.102710899
Data Source:  BioPlex
TRPC5
Tchem
Family:  IC
Novelty:  0.00406517
p_int:  0.847135158
p_ni:  0.152864842
Score:  0.54
Data Source:  BioPlex,STRINGDB
TMEM255A
Tdark
Novelty:  1.03700118
p_int:  0.812933651
p_ni:  0.187066346
p_wrong:  3e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC24 homolog B, COPII coat complex component
VGNC:7053
461431
Macaque
SEC24 homolog B, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:10704]
Mouse
MGI:2139764
99683
Rat
RGD:1309358
295461
Dog
SEC24 homolog B, COPII coat complex component
VGNC:45973
487898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC24 homolog B, COPII coat complex component
Macaque
SEC24 homolog B, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:10704]
Mouse
Rat
Dog
SEC24 homolog B, COPII coat complex component
Publication Statistics
PubMed Score 99.32
PubMed score by year
PubTator Score 43.25
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title