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Tbio
SEC24A
Protein transport protein Sec24A

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322887
  • ENSP00000321749
  • ENSG00000113615
  • ENST00000398844
  • ENSP00000381823
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.9
interacting protein
0.8
pathway
0.76
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.81   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.81   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (247)
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.998479007
p_ni:  0.001520993
Score:  0.993
Data Source:  BioPlex,STRINGDB
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.947041998
p_ni:  0.052958002
Data Source:  BioPlex
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
p_int:  0.93393751
p_ni:  0.06606249
Data Source:  BioPlex
RUBCNL
Tbio
Novelty:  0.20019585
p_int:  0.824474999
p_ni:  0.175525001
Score:  0.54
Data Source:  BioPlex,STRINGDB
UCN3
Tbio
Novelty:  0.00996251
p_int:  0.810954105
p_ni:  0.189045895
Data Source:  BioPlex
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
Score:  0.998
Data Source:  Reactome,STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.997
Data Source:  Reactome,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
Score:  0.995
Data Source:  Reactome,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.991
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
2
2
2
92.2
calcium measurement
2
2
2
85.1
puberty onset measurement
1
1
1
70.9
multiple sclerosis
1
1
0
1.1
68.6
age at first birth measurement
1
1
1
34.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
2
92.2
calcium measurement
2
85.1
puberty onset measurement
1
70.9
multiple sclerosis
0
1.1
68.6
age at first birth measurement
1
34.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC24 homolog A, COPII coat complex component
VGNC:4155
471787
Macaque
SEC24 homolog A, COPII coat complex component
711109
Mouse
MGI:1924621
77371
Rat
RGD:1309451
287275
Dog
SEC24 homolog A, COPII coat complex component
VGNC:45972
481510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC24 homolog A, COPII coat complex component
Macaque
SEC24 homolog A, COPII coat complex component
Mouse
Rat
Dog
SEC24 homolog A, COPII coat complex component
Publication Statistics
PubMed Score 15.81
PubMed score by year
PubTator Score 3.32
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title