You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SEC23A
Protein transport protein Sec23A

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity). The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307712
  • ENSP00000306881
  • ENSG00000100934
  • ENST00000537403
  • ENSP00000444193

Symbol
  • CLSD
  • hSec23A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
0.92
transcription factor perturbation
0.84
histone modification site profile
0.82
pathway
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.14   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.14   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (275)
SEC31A
Tbio
Novelty:  0.0350228
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.998
Data Source:  Reactome,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.998
Data Source:  Reactome,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
Score:  0.998
Data Source:  Reactome,STRINGDB
SAR1A
Tbio
Family:  Enzyme
Novelty:  0.0335242
Score:  0.994
Data Source:  STRINGDB
SEC16A
Tbio
Novelty:  0.02221416
Score:  0.993
Data Source:  Reactome,STRINGDB
SAR1B
Tbio
Family:  Enzyme
Novelty:  0.02260817
Score:  0.991
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
8
4
7
7
97.2
seasonality measurement
1
1
0
7
53.7
self reported educational attainment
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
7
7
97.2
seasonality measurement
0
7
53.7
self reported educational attainment
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sec23 homolog A, coat complex II component
VGNC:6788
452871
Macaque
Sec23 homolog A, coat complex II component
698500
Mouse
MGI:1349635
20334
Rat
RGD:1309103
58817
Dog
Sec23 homolog A, coat complex II component
VGNC:45969
480295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sec23 homolog A, coat complex II component
Macaque
Sec23 homolog A, coat complex II component
Mouse
Rat
Dog
Sec23 homolog A, coat complex II component
Publication Statistics
PubMed Score 30.14
PubMed score by year
PubTator Score 16.91
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title