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Tbio
SEC14L3
SEC14-like protein 3

Protein Summary
Description
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids. The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215812
  • ENSP00000215812
  • ENSG00000100012
  • ENST00000401751
  • ENSP00000383896
  • ENST00000402286
  • ENSP00000385004
  • ENST00000540910
  • ENSP00000439752

Symbol
  • TAP2
  • TAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.5
cellular component
0.45
metabolite
0.45
chemical
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
SEC14L4
Tbio
Novelty:  0.04131595
p_int:  1
Score:  0.698
Data Source:  BioPlex,STRINGDB
SEC14L2
Tbio
Novelty:  0.0092728
p_int:  0.999999899
p_wrong:  1.01e-7
Score:  0.697
Data Source:  BioPlex,STRINGDB
SPHK2
Tchem
Family:  Kinase
Novelty:  0.00454527
Score:  0.691
Data Source:  STRINGDB
PITPNB
Tbio
Novelty:  0.03432693
Score:  0.673
Data Source:  STRINGDB
RPS11
Tbio
Novelty:  0.0168881
Score:  0.627
Data Source:  STRINGDB
ANKIB1
Tdark
Novelty:  0.47935971
Score:  0.602
Data Source:  STRINGDB
PITPNA
Tbio
Novelty:  0.01901136
Score:  0.588
Data Source:  STRINGDB
CANX
Tbio
Novelty:  0.00087002
Score:  0.571
Data Source:  STRINGDB
PITPNM2
Tbio
Novelty:  0.0757684
Score:  0.492
Data Source:  STRINGDB
MOB1A
Tbio
Family:  Enzyme
Novelty:  0.01430129
Score:  0.479
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
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1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
93.1
sex hormone-binding globulin measurement
6
2
6
91.3
mean corpuscular volume
1
2
2
61.8
reticulocyte measurement
2
2
3
61.8
high density lipoprotein cholesterol measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
93.1
sex hormone-binding globulin measurement
6
91.3
mean corpuscular volume
2
61.8
reticulocyte measurement
3
61.8
high density lipoprotein cholesterol measurement
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC14 like lipid binding 3
VGNC:6711
470175
Macaque
SEC14 like lipid binding 3
715876
Mouse
MGI:3617848
380683
Rat
Cow
SEC14 like lipid binding 3
VGNC:53918
521133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC14 like lipid binding 3
Macaque
SEC14 like lipid binding 3
Mouse
Rat
Cow
SEC14 like lipid binding 3
Publication Statistics
PubMed Score 6.90
PubMed score by year
PubTator Score 3.31
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title