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Tbio
SEC14L2
SEC14-like protein 2

Protein Summary
Description
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402592
  • ENSP00000383882
  • ENSG00000100003
  • ENST00000405717
  • ENSP00000385186
  • ENST00000615189
  • ENSP00000478755

Symbol
  • C22orf6
  • KIAA1186
  • KIAA1658
  • SPF
  • TAP
  • TAP1
  • C22orf6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
disease perturbation
0.79
microRNA
0.72
cell type or tissue
0.61
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.08   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.08   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
SEC14L3
Tbio
Novelty:  0.15067161
p_int:  0.999999899
p_wrong:  1.01e-7
Score:  0.697
Data Source:  BioPlex,STRINGDB
OTC
Tchem
Family:  Enzyme
Novelty:  0.00544004
Score:  0.757
Data Source:  STRINGDB
RNASE1
Tchem
Family:  Enzyme
Novelty:  0.00198139
Score:  0.745
Data Source:  STRINGDB
PITPNB
Tbio
Novelty:  0.03432693
Score:  0.647
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.611
Data Source:  STRINGDB
SCARB1
Tchem
Novelty:  0.00087703
Score:  0.571
Data Source:  STRINGDB
PITPNA
Tbio
Novelty:  0.01901136
Score:  0.558
Data Source:  STRINGDB
PAOX
Tchem
Family:  Enzyme
Novelty:  0.00905719
Score:  0.531
Data Source:  STRINGDB
PIK3CG
Tclin
Family:  Kinase
Novelty:  0.00170533
Score:  0.52
Data Source:  STRINGDB
SPHK2
Tchem
Family:  Kinase
Novelty:  0.00454527
Score:  0.517
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
93.1
sex hormone-binding globulin measurement
6
2
6
91.3
platelet crit
2
2
2
82.5
mean corpuscular volume
1
2
2
61.8
reticulocyte measurement
2
2
3
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
93.1
sex hormone-binding globulin measurement
6
91.3
platelet crit
2
82.5
mean corpuscular volume
2
61.8
reticulocyte measurement
3
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915065
67815
Rat
RGD:621779
116486
Dog
SEC14 like lipid binding 2
477539
Horse
SEC14 like lipid binding 2
100058707
Cow
SEC14 like lipid binding 2
282469
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SEC14 like lipid binding 2
Horse
SEC14 like lipid binding 2
Cow
SEC14 like lipid binding 2
Publication Statistics
PubMed Score 100.08
PubMed score by year
PubTator Score 251.31
PubTator score by year
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Related Publications
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PMID
Year
Title