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Tbio
SEC14L1
SEC14-like protein 1

Protein Summary
Description
May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392476
  • ENSP00000376268
  • ENSG00000129657
  • ENST00000430767
  • ENSP00000408169
  • ENST00000431431
  • ENSP00000389838
  • ENST00000436233
  • ENSP00000390392
  • ENST00000443798
  • ENSP00000406030
  • ENST00000585618
  • ENSP00000466581
  • ENST00000591437
  • ENSP00000467934

Symbol
  • SEC14L
  • SEC14L
  • PRELID4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.99
transcription factor perturbation
0.96
disease perturbation
0.93
transcription factor
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
CCNDBP1
Tbio
Novelty:  0.01527762
p_int:  0.999999606
p_ni:  3.92e-7
p_wrong:  2e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
CDH13
Tbio
Novelty:  0.00389516
p_int:  0.99999869
p_ni:  0.00000131
Score:  0.169
Data Source:  BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.999997315
p_ni:  0.000002685
Score:  0.185
Data Source:  BioPlex,STRINGDB
C2CD2
Tdark
Novelty:  0.34079266
p_int:  0.999997213
p_ni:  0.000002787
Score:  0.538
Data Source:  BioPlex,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.999976577
p_ni:  0.000023384
p_wrong:  3.9e-8
Score:  0.27
Data Source:  BioPlex,STRINGDB
CD70
Tbio
Novelty:  0.00420393
p_int:  0.999965226
p_ni:  0.000028311
p_wrong:  0.000006463
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.999672003
p_ni:  0.000304663
p_wrong:  0.000023334
Data Source:  BioPlex
PTPN9
Tchem
Family:  Enzyme
Novelty:  0.01574113
Score:  0.905
Data Source:  STRINGDB
SEPT9
Tchem
Novelty:  0.00407266
Score:  0.807
Data Source:  STRINGDB
SESTD1
Tbio
Novelty:  0.2052002
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
NRF2 pathway
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Tamoxifen metabolism
Name
Explore in Pharos
Explore in Source
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
NRF2 pathway
Metapathway biotransformation Phase I and II
Tamoxifen metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
49.5
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
49.5
1
0.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SEC14 like lipid binding 1
708394
Mouse
MGI:1921386
74136
Rat
RGD:1563123
360668
Dog
SEC14 like lipid binding 1
VGNC:45963
483338
Horse
SEC14 like lipid binding 1
VGNC:22784
100050884
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SEC14 like lipid binding 1
Mouse
Rat
Dog
SEC14 like lipid binding 1
Horse
SEC14 like lipid binding 1
Publication Statistics
PubMed Score 10.45
PubMed score by year
PubTator Score 5.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title