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Tbio
SEC11A
Signal peptidase complex catalytic subunit SEC11A

Protein Summary
Description
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268220
  • ENSP00000268220
  • ENSG00000140612
  • ENST00000455959
  • ENSP00000413121
  • ENST00000558134
  • ENSP00000452697
  • ENST00000560266
  • ENSP00000452684

Symbol
  • SEC11L1
  • SPC18
  • SPCS4A
  • SPC18
  • SPCS4A
  • SEC11L1
  • sid2895
  • 1810012E07Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
kinase perturbation
0.95
protein domain
0.85
transcription factor binding site profile
0.78


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
SPCS2
Tbio
Family:  Enzyme
Novelty:  0.21358992
p_int:  0.998197266
p_ni:  0.001802734
Score:  0.992
Data Source:  BioPlex,STRINGDB
SPCS3
Tbio
Family:  Enzyme
Novelty:  0.13677259
p_int:  0.988533555
p_ni:  0.011466445
Score:  0.997
Data Source:  BioPlex,STRINGDB
SPCS1
Tbio
Family:  Enzyme
Novelty:  0.0731223
p_int:  0.960071098
p_ni:  0.004469262
p_wrong:  0.03545964
Score:  0.996
Data Source:  BioPlex,STRINGDB
GPC1
Tbio
Novelty:  0.00293087
p_int:  0.808172458
p_ni:  0.191827542
Score:  0.396
Data Source:  BioPlex,STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.985
Data Source:  STRINGDB
SSR3
Tbio
Novelty:  0.05838475
Score:  0.979
Data Source:  STRINGDB
SSR4
Tbio
Novelty:  0.04072695
Score:  0.978
Data Source:  STRINGDB
SSR2
Tbio
Novelty:  0.01383689
Score:  0.973
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.95
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Incretin synthesis, secretion, and inactivation (R-HSA-400508)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Synthesis, secretion, and deacylation of Ghrelin
Name
Explore in Pharos
Explore in Source
Incretin synthesis, secretion, and inactivation
Metabolism of proteins
Peptide hormone metabolism
SRP-dependent cotranslational protein targeting to membrane
Synthesis, secretion, and deacylation of Ghrelin
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
6
5
2
1.1
91.1
BMI-adjusted hip circumference
2
5
5
75.9
transmembrane glycoprotein NMB measurement
1
1
1
66.5
glomerular filtration rate
3
1
3
61
2
2
2
58.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
2
1.1
91.1
BMI-adjusted hip circumference
5
75.9
transmembrane glycoprotein NMB measurement
1
66.5
glomerular filtration rate
3
61
2
58.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC11 homolog A, signal peptidase complex subunit
VGNC:7523
453607
Macaque
SEC11 homolog A, signal peptidase complex subunit
695951
Mouse
MGI:1929464
56529
Rat
RGD:69360
65166
Dog
SEC11 homolog A, signal peptidase complex subunit
VGNC:53239
404004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC11 homolog A, signal peptidase complex subunit
Macaque
SEC11 homolog A, signal peptidase complex subunit
Mouse
Rat
Dog
SEC11 homolog A, signal peptidase complex subunit
Publication Statistics
PubMed Score 23.18
PubMed score by year
PubTator Score 4.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title