Protein Summary
Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet ...more
- ENST00000392650
- ENSP00000376421
- ENSG00000069188
- KIAA1514
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
microRNA | 0.72 | ||
transcription factor binding site profile | 0.63 | ||
tissue sample | 0.62 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.84 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 17 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.84 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 17 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (52)
CLU
Novelty: 0.00054776
p_int: 0.999979449
p_ni: 0.000020551
Score: 0.202
Data Source: BioPlex,STRINGDB
TMEM30B
Novelty: 0.26735006
p_int: 0.999929598
p_ni: 0.000069762
p_wrong: 6.39e-7
Data Source: BioPlex
PCDHGB1
Novelty: 0.60440805
p_int: 0.999809605
p_ni: 0.000189789
p_wrong: 6.06e-7
Score: 0.18
Data Source: BioPlex,STRINGDB
CEACAM21
Novelty: 0.46116153
p_int: 0.996454207
p_ni: 0.002671434
p_wrong: 0.000874359
Data Source: BioPlex
RAET1E
Novelty: 0.01859274
p_int: 0.995825013
p_ni: 0.003708595
p_wrong: 0.000466391
Score: 0.179
Data Source: BioPlex,STRINGDB
ADAM17
Family: Enzyme
Novelty: 0.00121971
p_int: 0.992623704
p_ni: 0.00561797
p_wrong: 0.001758326
Score: 0.232
Data Source: BioPlex,STRINGDB
FAM19A5
Novelty: 0.07792418
p_int: 0.989830516
p_ni: 0.010169483
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | SDK interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
SDK interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sidekick cell adhesion molecule 2 | VGNC:9588 | 454860 | |||||
Mouse | MGI:2443847 | 237979 | ||||||
Rat | RGD:1310397 | 360652 | ||||||
Dog | sidekick cell adhesion molecule 2 | VGNC:45954 | 483283 | |||||
Horse | sidekick cell adhesion molecule 2 | VGNC:22776 | 100061116 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sidekick cell adhesion molecule 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sidekick cell adhesion molecule 2 | |||||
Horse | sidekick cell adhesion molecule 2 | |||||
Publication Statistics
PubMed Score 10.84
PubMed score by year
PubTator Score 3.50
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
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