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Tbio
SDK1
Protein sidekick-1

Protein Summary
Description
Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404826
  • ENSP00000385899
  • ENSG00000146555
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.85
transcription factor binding site profile
0.78
cell type or tissue
0.73
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.23   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.23   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999999932
p_ni:  1.3e-8
p_wrong:  5.5e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999996565
p_ni:  0.00000155
p_wrong:  0.000001885
Score:  0.201
Data Source:  BioPlex,STRINGDB
DRG1
Tbio
Novelty:  0.32024564
Score:  0.62
Data Source:  STRINGDB
FLRT1
Tdark
Novelty:  0.23047852
Score:  0.619
Data Source:  STRINGDB
ARHGAP1
Tbio
Family:  Enzyme
Novelty:  0.00668626
Score:  0.592
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.543
Data Source:  STRINGDB
CBFA2T3
Tbio
Novelty:  0.01235845
Score:  0.536
Data Source:  STRINGDB
ABLIM2
Tdark
Novelty:  0.23629309
Score:  0.531
Data Source:  STRINGDB
MIA2
Tbio
Novelty:  0.0931387
Score:  0.527
Data Source:  STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
Score:  0.521
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
SDK interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
SDK interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
7
8
93.6
smoking status measurement
3
2
3
1
89.4
smoking initiation
3
3
3
85.2
self reported educational attainment
1
1
1
75.4
smoking behavior
1
2
2
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
8
93.6
smoking status measurement
3
1
89.4
smoking initiation
3
85.2
self reported educational attainment
1
75.4
smoking behavior
2
71.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sidekick cell adhesion molecule 1
VGNC:4502
463240
Macaque
sidekick cell adhesion molecule 1
715160
Mouse
MGI:2444413
330222
Dog
sidekick cell adhesion molecule 1
VGNC:45953
489886
Horse
sidekick cell adhesion molecule 1
VGNC:22775
100060475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sidekick cell adhesion molecule 1
Macaque
sidekick cell adhesion molecule 1
Mouse
Dog
sidekick cell adhesion molecule 1
Horse
sidekick cell adhesion molecule 1
Publication Statistics
PubMed Score 23.23
PubMed score by year
PubTator Score 7.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title