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Tbio
SDHC
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Protein Summary
Description
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342751
  • ENSP00000356952
  • ENSG00000143252
  • ENST00000367975
  • ENSP00000356953
  • ENST00000392169
  • ENSP00000376009
  • ENST00000432287
  • ENSP00000390558
  • ENST00000513009
  • ENSP00000423260

Symbol
  • CYB560
  • SDH3
  • CYBL
  • PGL3
  • QPS1
  • SDH3
  • CYB560
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.97
cellular component
0.91
transcription factor binding site profile
0.84
co-expressed gene
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.07   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.07   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (306)
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999996898
p_ni:  4.4e-8
p_wrong:  0.000003058
Score:  0.24
Data Source:  BioPlex,STRINGDB
SDHD
Tbio
Family:  Enzyme
Novelty:  0.00167904
p_int:  0.903124856
p_ni:  0.000005764
p_wrong:  0.09686938
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
Score:  0.999
Data Source:  Reactome,STRINGDB
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
Score:  0.999
Data Source:  Reactome,STRINGDB
FH
Tbio
Family:  Enzyme
Novelty:  0.00455957
Score:  0.991
Data Source:  STRINGDB
SUCLG1
Tbio
Family:  Enzyme
Novelty:  0.01113643
Score:  0.99
Data Source:  STRINGDB
NDUFS2
Tclin
Family:  Enzyme
Novelty:  0.02347576
Score:  0.979
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.968
Data Source:  STRINGDB
SUCLA2
Tchem
Family:  Enzyme
Novelty:  0.02029861
Score:  0.963
Data Source:  STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
Score:  0.96
Data Source:  STRINGDB
Pathways (20)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
4
4
93.4
blood protein measurement
1
4
4
93.2
mean platelet volume
3
2
4
93
blood metabolite measurement
2
2
2
83
4
2
0
1.1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
4
93.4
blood protein measurement
4
93.2
mean platelet volume
4
93
blood metabolite measurement
2
83
0
1.1
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
succinate dehydrogenase complex subunit C
719978
Mouse
MGI:1913302
66052
Rat
RGD:1359454
289217
Dog
succinate dehydrogenase complex subunit C
VGNC:45952
478983
Horse
succinate dehydrogenase complex subunit C
VGNC:22774
100065940
Species
Name
OMA
EggNOG
Inparanoid
Macaque
succinate dehydrogenase complex subunit C
Mouse
Rat
Dog
succinate dehydrogenase complex subunit C
Horse
succinate dehydrogenase complex subunit C
Publication Statistics
PubMed Score 1206.07
PubMed score by year
PubTator Score 425.30
PubTator score by year
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Related Publications
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PMID
Year
Title