Tbio SDHC Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Protein Summary

Description

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q99643
• O75609
• Q3C259
• Q3C2D8
• Q3C2H4
• Q5VTH3

Gene Name

• SDHC

Ensembl ID

• ENST00000342751
• ENSP00000356952
• ENSG00000143252
• ENST00000367975
• ENSP00000356953
• ENST00000392169
• ENSP00000376009
• ENST00000432287
• ENSP00000390558
• ENST00000513009
• ENSP00000423260

Symbol

• CYB560
• SDH3
• CYBL
• PGL3
• QPS1
• SDH3
• CYB560

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.97
cellular component	0.91
transcription factor binding site profile	0.84
co-expressed gene	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.07   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.07   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (306)

Explore Interacting Targets

1 – 10 of 306

• See Interactions on String-DB

IMPDH1

Tclin

Family:  Enzyme

Novelty:  0.00758575

p_int:  0.999996898

p_ni:  4.4e-8

p_wrong:  0.000003058

Score:  0.24

Data Source:  BioPlex,STRINGDB

SDHD

Tbio

Family:  Enzyme

Novelty:  0.00167904

p_int:  0.903124856

p_ni:  0.000005764

p_wrong:  0.09686938

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SDHB

Tchem

Family:  Enzyme

Novelty:  0.0010199

Score:  0.999

Data Source:  Reactome,STRINGDB

SDHA

Tbio

Family:  Enzyme

Novelty:  0.00223171

Score:  0.999

Data Source:  Reactome,STRINGDB

FH

Tbio

Family:  Enzyme

Novelty:  0.00455957

Score:  0.991

Data Source:  STRINGDB

SUCLG1

Tbio

Family:  Enzyme

Novelty:  0.01113643

Score:  0.99

Data Source:  STRINGDB

NDUFS2

Tclin

Family:  Enzyme

Novelty:  0.02347576

Score:  0.979

Data Source:  STRINGDB

CYCS

Tchem

Novelty:  0.00014004

Score:  0.968

Data Source:  STRINGDB

SUCLA2

Tchem

Family:  Enzyme

Novelty:  0.02029861

Score:  0.963

Data Source:  STRINGDB

ATP5F1D

Tbio

Family:  Enzyme

Novelty:  0.07296539

Score:  0.96

Data Source:  STRINGDB

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Downstream (1)

1 – 1 of 1

IDH2

Tclin

Family:  Enzyme

KEGG Distance:  4

Common Pathways:  3

1: Citrate cycle (TCA cycle)

2: Carbon metabolism

3: Metabolic pathways

Pathways (20)

Reactome (6)

KEGG (9)

PathwayCommons (1)

UniProt (1)

WikiPathways (3)

Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Citric acid cycle (TCA cycle)	22 targets	R-HSA-71403
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Pyruvate metabolism and Citric Acid (TCA) cycle	55 targets	R-HSA-71406
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200

Name	Explore in Pharos	Explore in Source
Citric acid cycle (TCA cycle)	22 targets	R-HSA-71403
Metabolism	2112 targets	R-HSA-1430728
Pyruvate metabolism and Citric Acid (TCA) cycle	55 targets	R-HSA-71406
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (5)

Components (5)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
electron transfer activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquinone binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
heme binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
succinate dehydrogenase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum non-albumin protein measurement	EFO_0004568	1	4	4		93.4
blood protein measurement	EFO_0007937	1	4	4		93.2
mean platelet volume	EFO_0004584	3	2	4		93
blood metabolite measurement	EFO_0005664	2	2	2		83
allergic rhinitis	EFO_0005854	4	2	0	1.1	82.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum non-albumin protein measurement	EFO_0004568	4		93.4
blood protein measurement	EFO_0007937	4		93.2
mean platelet volume	EFO_0004584	4		93
blood metabolite measurement	EFO_0005664	2		83
allergic rhinitis	EFO_0005854	0	1.1	82.8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
allergic rhinitis
allergy
asthma
blood metabolite measurement
blood protein measurement
childhood onset asthma
Eczema
leukocyte count
lipoprotein measurement
mean corpuscular hemoglobin concentration

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	succinate dehydrogenase complex subunit C		719978
Mouse	succinate dehydrogenase complex, subunit C, integral membrane protein	MGI:1913302	66052
Rat	succinate dehydrogenase complex subunit C	RGD:1359454	289217
Dog	succinate dehydrogenase complex subunit C	VGNC:45952	478983
Horse	succinate dehydrogenase complex subunit C	VGNC:22774	100065940

Species	Name	OMA	EggNOG	Inparanoid
Macaque	succinate dehydrogenase complex subunit C
Mouse	succinate dehydrogenase complex, subunit C, integral membrane protein
Rat	succinate dehydrogenase complex subunit C
Dog	succinate dehydrogenase complex subunit C
Horse	succinate dehydrogenase complex subunit C

Publication Statistics

PubMed Score 1206.07

PubMed score by year

Reset Zoom

PubTator Score 425.30

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (69)

GeneRif Annotations (41)

Items per page:

10

0 of 0

PMID	Year	Title