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Tbio
SDHAF3
Succinate dehydrogenase assembly factor 3, mitochondrial

Protein Summary
Description
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432641
  • ENSP00000414066
  • ENSG00000196636

Symbol
  • ACN9
  • ACN9
  • DC11
  • Sdh7
  • LYRM10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
transcription factor binding site profile
0.73
kinase perturbation
0.71
phenotype
0.69
cell line
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.84   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.84   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
p_int:  0.999999993
p_ni:  7e-9
Score:  0.978
Data Source:  BioPlex,STRINGDB
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
p_int:  0.998216176
p_ni:  0.001783824
Score:  0.94
Data Source:  BioPlex,STRINGDB
SDHAF4
Tbio
Family:  Enzyme
Novelty:  0.24150488
p_int:  0.967030027
p_ni:  0.000001041
p_wrong:  0.032968932
Score:  0.977
Data Source:  BioPlex,STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
p_int:  0.966928736
p_ni:  0.033071264
Score:  0.878
Data Source:  BioPlex,STRINGDB
SDHAF1
Tbio
Family:  Enzyme
Novelty:  0.1401114
Score:  0.862
Data Source:  STRINGDB
LYRM2
Tdark
Novelty:  0.33936166
Score:  0.802
Data Source:  STRINGDB
LYRM4
Tbio
Novelty:  0.03319832
Score:  0.784
Data Source:  STRINGDB
NUBPL
Tbio
Novelty:  0.01059986
Score:  0.704
Data Source:  STRINGDB
LYRM7
Tbio
Novelty:  0.16270565
Score:  0.698
Data Source:  STRINGDB
SLC22A23
Tbio
Family:  Transporter
Novelty:  0.23405744
Score:  0.687
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
89.9
bone density
1
2
2
28
alkaline phosphatase measurement
1
1
1
11.1
self reported educational attainment
1
1
1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
89.9
bone density
2
28
alkaline phosphatase measurement
1
11.1
self reported educational attainment
1
8.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
succinate dehydrogenase complex assembly factor 3
VGNC:14084
747629
Macaque
succinate dehydrogenase complex assembly factor 3
697593
Mouse
MGI:1913288
71238
Rat
RGD:1305143
362323
Dog
succinate dehydrogenase complex assembly factor 3
VGNC:45950
610248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
succinate dehydrogenase complex assembly factor 3
Macaque
succinate dehydrogenase complex assembly factor 3
Mouse
Rat
Dog
succinate dehydrogenase complex assembly factor 3
Publication Statistics
PubMed Score 66.84
PubMed score by year
PubTator Score 15.90
PubTator score by year
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Related Publications
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PMID
Year
Title