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Tbio
SDF4
45 kDa calcium-binding protein

Protein Summary
Description
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263741
  • ENSP00000263741
  • ENSG00000078808
  • ENST00000360001
  • ENSP00000353094

Symbol
  • CAB45
  • Cab45
  • SDF-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.97
transcription factor binding site profile
0.83
cellular component
0.75
histone modification site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 687.05   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 687.05   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.999697584
p_ni:  0.000302416
Data Source:  BioPlex
KSR1
Tbio
Family:  Kinase
Novelty:  0.00691155
p_int:  0.998710774
p_ni:  0.001085184
p_wrong:  0.000204042
Score:  0.188
Data Source:  BioPlex,STRINGDB
CHST11
Tbio
Family:  Enzyme
Novelty:  0.02528458
p_int:  0.997229783
p_ni:  0.00242944
p_wrong:  0.000340777
Score:  0.188
Data Source:  BioPlex,STRINGDB
TTC28
Tdark
Novelty:  0.16651519
p_int:  0.991566914
p_ni:  0.008385487
p_wrong:  0.000047598
Data Source:  BioPlex
MYO9B
Tbio
Novelty:  0.0164265
p_int:  0.985343287
p_ni:  0.014656713
Score:  0.198
Data Source:  BioPlex,STRINGDB
KIAA1671
Tdark
Novelty:  1.1816849
p_int:  0.981797346
p_ni:  0.018202653
p_wrong:  1e-9
Data Source:  BioPlex
RICTOR
Tbio
Novelty:  0.00250734
p_int:  0.973497984
p_ni:  0.026501994
p_wrong:  2.2e-8
Data Source:  BioPlex
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.971646929
p_ni:  0.028332534
p_wrong:  0.000020537
Data Source:  BioPlex
MTFR1L
Tdark
Novelty:  3.23781609
p_int:  0.967806277
p_ni:  0.0297321
p_wrong:  0.002461623
Data Source:  BioPlex
ARL8B
Tbio
Family:  Enzyme
Novelty:  0.06939851
p_int:  0.967442147
p_ni:  0.032557852
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
1
1
0
1.1
35
calcium measurement
1
1
1
21.3
urate measurement
2
1
2
12.2
hair color
1
1
0
1.1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
0
1.1
35
calcium measurement
1
21.3
urate measurement
2
12.2
hair color
0
1.1
8.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
stromal cell derived factor 4
699804
Mouse
MGI:108079
20318
Rat
RGD:621521
155173
Dog
stromal cell derived factor 4
VGNC:45948
479572
Horse
stromal cell derived factor 4
VGNC:22770
100066142
Species
Name
OMA
EggNOG
Inparanoid
Macaque
stromal cell derived factor 4
Mouse
Rat
Dog
stromal cell derived factor 4
Horse
stromal cell derived factor 4
Publication Statistics
PubMed Score 687.05
PubMed score by year
PubTator Score 11.42
PubTator score by year
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Related Publications
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PMID
Year
Title