Tbio SDF4 45 kDa calcium-binding protein

Protein Summary

Description

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q9BRK5
• B1AME5
• B1AME6
• B2RDF1
• B4DSM1
• Q53G52
• Q53HQ9
• Q8NBQ3
• Q96AA1
• Q9NZP7
• Q9UN53
• Cab45

Gene Name

• SDF4

Ensembl ID

• ENST00000263741
• ENSP00000263741
• ENSG00000078808
• ENST00000360001
• ENSP00000353094

Symbol

• CAB45
• Cab45
• SDF-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.97
transcription factor binding site profile	0.83
cellular component	0.75
histone modification site profile	0.74

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / 45 Kda Calcium-binding Protein

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / 45 Kda Calcium-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 687.05   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 687.05   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

ACAD11

Tbio

Family:  Enzyme

Novelty:  0.22908145

p_int:  0.999697584

p_ni:  0.000302416

Data Source:  BioPlex

KSR1

Tbio

Family:  Kinase

Novelty:  0.00691155

p_int:  0.998710774

p_ni:  0.001085184

p_wrong:  0.000204042

Score:  0.188

Data Source:  BioPlex,STRINGDB

CHST11

Tbio

Family:  Enzyme

Novelty:  0.02528458

p_int:  0.997229783

p_ni:  0.00242944

p_wrong:  0.000340777

Score:  0.188

Data Source:  BioPlex,STRINGDB

TTC28

Tdark

Novelty:  0.16651519

p_int:  0.991566914

p_ni:  0.008385487

p_wrong:  0.000047598

Data Source:  BioPlex

MYO9B

Tbio

Novelty:  0.0164265

p_int:  0.985343287

p_ni:  0.014656713

Score:  0.198

Data Source:  BioPlex,STRINGDB

KIAA1671

Tdark

Novelty:  1.1816849

p_int:  0.981797346

p_ni:  0.018202653

p_wrong:  1e-9

Data Source:  BioPlex

RICTOR

Tbio

Novelty:  0.00250734

p_int:  0.973497984

p_ni:  0.026501994

p_wrong:  2.2e-8

Data Source:  BioPlex

FHL2

Tbio

Novelty:  0.00501273

p_int:  0.971646929

p_ni:  0.028332534

p_wrong:  0.000020537

Data Source:  BioPlex

MTFR1L

Tdark

Novelty:  3.23781609

p_int:  0.967806277

p_ni:  0.0297321

p_wrong:  0.002461623

Data Source:  BioPlex

ARL8B

Tbio

Family:  Enzyme

Novelty:  0.06939851

p_int:  0.967442147

p_ni:  0.032557852

p_wrong:  1e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (2)

Components (9)

Processes (6)

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1 – 2 of 2

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	BHF-UCL
identical protein binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
inflammatory bowel disease	EFO_0003767	2	1	0	1.1	56.2
ulcerative colitis	EFO_0000729	1	1	0	1.1	35
calcium measurement	EFO_0004838	1	1	1		21.3
urate measurement	EFO_0004531	2	1	2		12.2
hair color	EFO_0003924	1	1	0	1.1	8.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
inflammatory bowel disease	EFO_0003767	0	1.1	56.2
ulcerative colitis	EFO_0000729	0	1.1	35
calcium measurement	EFO_0004838	1		21.3
urate measurement	EFO_0004531	2		12.2
hair color	EFO_0003924	0	1.1	8.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Exocytosis
Glycoprotein
Golgi apparatus
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
calcium measurement
hair color
inflammatory bowel disease
Thyroid preparation use measurement
ulcerative colitis
urate measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	stromal cell derived factor 4		699804
Mouse	stromal cell derived factor 4	MGI:108079	20318
Rat	stromal cell derived factor 4	RGD:621521	155173
Dog	stromal cell derived factor 4	VGNC:45948	479572
Horse	stromal cell derived factor 4	VGNC:22770	100066142

Species	Name	OMA	EggNOG	Inparanoid
Macaque	stromal cell derived factor 4
Mouse	stromal cell derived factor 4
Rat	stromal cell derived factor 4
Dog	stromal cell derived factor 4
Horse	stromal cell derived factor 4

Publication Statistics

PubMed Score 687.05

PubMed score by year

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PubTator Score 11.42

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (11)

Items per page:

10

0 of 0

PMID	Year	Title