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Tbio
SDCCAG8
Serologically defined colon cancer antigen 8

Protein Summary
Description
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis. This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366541
  • ENSP00000355499
  • ENSG00000054282
  • ENST00000622598
  • ENSP00000483550
  • ENSG00000276111

Symbol
  • CCCAP
  • NPHP10
  • BBS16
  • CCCAP
  • SLSN7
  • NPHP10
  • hCCCAP
  • HSPC085
  • NY-CO-8
  • CCCAP SLSN7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
transcription factor binding site profile
0.88
transcription factor
0.86
virus perturbation
0.79
phenotype
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.05   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.05   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.999999983
p_ni:  8e-9
p_wrong:  9e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999999919
p_ni:  7.9e-8
p_wrong:  1e-9
Data Source:  BioPlex
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.999997285
p_ni:  0.000002715
Score:  0.209
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999993629
p_ni:  0.000006279
p_wrong:  9.3e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
p_int:  0.999993578
p_ni:  0.000006412
p_wrong:  1e-8
Score:  0.686
Data Source:  BioPlex,STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.999988727
p_ni:  0.000011152
p_wrong:  1.21e-7
Score:  0.741
Data Source:  BioPlex,STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.981
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.981
Data Source:  STRINGDB
IQCB1
Tbio
Novelty:  0.02979098
Score:  0.98
Data Source:  STRINGDB
OFD1
Tbio
Novelty:  0.01032841
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (64)
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
7
6
5.9
97.2
self reported educational attainment
5
7
6
5.9
97.2
schizophrenia
10
9
4
1.1
96
schizophrenia
10
9
4
1.1
96
glomerular filtration rate
8
4
8
6.7
95.9
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
5.9
97.2
self reported educational attainment
6
5.9
97.2
schizophrenia
4
1.1
96
schizophrenia
4
1.1
96
glomerular filtration rate
8
6.7
95.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serologically defined colon cancer antigen 8
469732
Macaque
serologically defined colon cancer antigen 8
705545
Mouse
MGI:1924066
76816
Rat
RGD:727781
305002
Dog
serologically defined colon cancer antigen 8
490374
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serologically defined colon cancer antigen 8
Macaque
serologically defined colon cancer antigen 8
Mouse
Rat
Dog
serologically defined colon cancer antigen 8
Publication Statistics
PubMed Score 33.05
PubMed score by year
PubTator Score 10.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title