Tbio SDCBP2 Syntenin-2

Protein Summary

Description

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q9H190
• O95892
• Q5W0X1
• Q9BZ42
• Q9H567
• Q9NRY8

Gene Name

• SDCBP2

Ensembl ID

• ENST00000339987
• ENSP00000342935
• ENSG00000125775
• ENST00000360779
• ENSP00000354013
• ENST00000381808
• ENSP00000371229
• ENST00000381812
• ENSP00000371233

Symbol

• SITAC18
• ST2
• ST-2
• SITAC
• SITAC18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	1
gene perturbation	0.65
transcription factor	0.62
cell type or tissue	0.58
tissue sample	0.54

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Syntenin-2

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Syntenin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.42   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.42   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0