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Tchem
SDCBP
Syntenin-1

Protein Summary
Description
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260130
  • ENSP00000260130
  • ENSG00000137575
  • ENST00000413219
  • ENSP00000411771
  • ENST00000424270
  • ENSP00000395351
  • ENST00000447182
  • ENSP00000409288

Symbol
  • MDA9
  • SYCL
  • ST1
  • MDA9
  • SYCL
  • MDA-9
  • TACIP18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.97
virus perturbation
0.94
cellular component
0.92
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.64   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.64   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (211)
TARSL2
Tbio
Family:  Enzyme
Novelty:  0.02406282
p_int:  0.999942988
p_ni:  0.000057012
Score:  0.524
Data Source:  BioPlex,STRINGDB
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.999764334
p_ni:  0.000235666
Score:  0.828
Data Source:  BioPlex,STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.999487762
p_ni:  0.000512238
Score:  0.821
Data Source:  BioPlex,STRINGDB
AIMP2
Tchem
Family:  Enzyme
Novelty:  0.03283387
p_int:  0.997768809
p_ni:  0.002231191
Score:  0.815
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.99687154
p_ni:  0.00312846
Data Source:  BioPlex
PCDHGA7
Tdark
Novelty:  1.67766171
p_int:  0.995036579
p_ni:  0.004955934
p_wrong:  0.000007487
Data Source:  BioPlex
WRAP73
Tbio
Novelty:  0.25394934
p_int:  0.993808405
p_ni:  0.006191595
Data Source:  BioPlex
LTBR
Tbio
Novelty:  0.003823
p_int:  0.991972423
p_ni:  0.008027577
Data Source:  BioPlex
DARS
Tbio
Family:  Enzyme
Novelty:  0.01101888
p_int:  0.983480748
p_ni:  0.016519252
Score:  0.817
Data Source:  BioPlex,STRINGDB
PSME2
Tbio
Novelty:  0.02624268
p_int:  0.978393776
p_ni:  0.02068423
p_wrong:  0.000921994
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
Ephrin signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
Ephrin signaling
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
25
11
34
98.1
total cholesterol measurement
17
11
25
97.5
triglyceride measurement
18
8
19
95.6
apolipoprotein B measurement
3
4
4
93.1
serum gamma-glutamyl transferase measurement
2
3
3
87.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
34
98.1
total cholesterol measurement
25
97.5
triglyceride measurement
19
95.6
apolipoprotein B measurement
4
93.1
serum gamma-glutamyl transferase measurement
3
87.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syndecan binding protein
VGNC:800
464192
Macaque
syndecan binding protein
698381
Mouse
MGI:1337026
53378
Rat
RGD:621497
83841
Dog
syndecan binding protein
482977
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syndecan binding protein
Macaque
syndecan binding protein
Mouse
Rat
Dog
syndecan binding protein
Publication Statistics
PubMed Score 647.64
PubMed score by year
PubTator Score 275.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title