Protein Summary
Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]
- ENST00000339394
- ENSP00000344468
- ENSG00000162512
- KIAA0468
- SDCN
- SYND3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.67 | ||
PubMedID | 0.66 | ||
histone modification site profile | 0.65 | ||
virus perturbation | 0.64 | ||
small molecule perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 95.81 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 212 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 95.81 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 212 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (128)
Nearest Tclin Targets
Pathways (41)
Reactome (29)
KEGG (1)
PathwayCommons (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Reactome | Defective B3GAT3 causes JDSSDHD | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Cell surface interactions at the vascular wall | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Defective B3GAT3 causes JDSSDHD | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 1 | 1 | 1 | 74.2 | |||||
hip circumference | 1 | 1 | 1 | 73.6 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 56.4 | |||||
testosterone measurement | 1 | 1 | 1 | 4.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 1 | 74.2 | |||||
hip circumference | 1 | 73.6 | |||||
sex hormone-binding globulin measurement | 2 | 56.4 | |||||
testosterone measurement | 1 | 4.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | syndecan 3 | VGNC:1536 | 744364 | |||||
Macaque | syndecan 3 | 704374 | ||||||
Mouse | MGI:1349163 | 20970 | ||||||
Rat | RGD:621486 | 116673 | ||||||
Dog | syndecan 3 | VGNC:45943 | 487323 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | syndecan 3 | |||||
Macaque | syndecan 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syndecan 3 | |||||
Publication Statistics
PubMed Score 95.81
PubMed score by year
PubTator Score 53.12
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
|---|