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Tbio
SDC1
Syndecan-1

Protein Summary
Description
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254351
  • ENSP00000254351
  • ENSG00000115884
  • ENST00000381150
  • ENSP00000370542

Symbol
  • SDC
  • SDC
  • CD138
  • SYND1
  • syndecan
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.93
biological process
0.91
disease perturbation
0.87
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2915.76   (req: < 5)
Gene RIFs: 258   (req: <= 3)
Antibodies: 1362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2915.76   (req: >= 5)
Gene RIFs: 258   (req: > 3)
Antibodies: 1362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (320)
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.999999794
p_ni:  6.4e-8
p_wrong:  1.43e-7
Data Source:  BioPlex
FARP1
Tbio
Novelty:  0.04040696
p_int:  0.999995054
p_ni:  0.000004946
Score:  0.257
Data Source:  BioPlex,STRINGDB
DHRS2
Tbio
Family:  Enzyme
Novelty:  0.002032
p_int:  0.999978149
p_ni:  0.000008227
p_wrong:  0.000013624
Score:  0.313
Data Source:  BioPlex,STRINGDB
GMEB2
Tdark
Family:  TF
Novelty:  0.1945427
p_int:  0.999970602
p_ni:  0.000028782
p_wrong:  6.16e-7
Score:  0.663
Data Source:  BioPlex,STRINGDB
FGF2
Tchem
Novelty:  0.00007856
p_int:  0.999918517
p_ni:  0.00000195
p_wrong:  0.000079534
Score:  0.981
Data Source:  BioPlex,STRINGDB
PRDM10
Tbio
Family:  TF; Epigenetic
Novelty:  0.03463517
p_int:  0.99975567
p_ni:  0.000244327
p_wrong:  3e-9
Score:  0.299
Data Source:  BioPlex,STRINGDB
CYHR1
Tdark
Novelty:  0.04771996
p_int:  0.999722829
p_ni:  0.000275122
p_wrong:  0.000002049
Data Source:  BioPlex
EPHA2
Tclin
Family:  Kinase
Novelty:  0.00191002
p_int:  0.998340724
p_ni:  0.001659276
Score:  0.414
Data Source:  BioPlex,STRINGDB
CSNK1G3
Tchem
Family:  Kinase
Novelty:  0.07584067
p_int:  0.997757967
p_ni:  0.002242033
Data Source:  BioPlex
OCLN
Tbio
Novelty:  0.00047671
p_int:  0.997355459
p_ni:  0.002644539
p_wrong:  2e-9
Score:  0.267
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 5 of 7
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
FGFR1
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
RAF1
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
Pathways (52)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Cell surface interactions at the vascular wall
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Cytokine Signaling in Immune system
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Cell surface interactions at the vascular wall
Chondroitin sulfate/dermatan sulfate metabolism
Cytokine Signaling in Immune system
Defective B3GALT6 causes EDSP2 and SEMDJL1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
31
6
31
91
sex hormone-binding globulin measurement
6
3
6
87.6
low density lipoprotein cholesterol measurement
5
4
6
85.4
testosterone measurement
6
2
5
7.8
83.3
apolipoprotein A 1 measurement
2
3
3
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
31
91
sex hormone-binding globulin measurement
6
87.6
low density lipoprotein cholesterol measurement
6
85.4
testosterone measurement
5
7.8
83.3
apolipoprotein A 1 measurement
3
82.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
syndecan 1
701544
Mouse
MGI:1349162
20969
Rat
RGD:3648
25216
Dog
syndecan 1
VGNC:45942
482986
Horse
syndecan 1
VGNC:22761
100071892
Species
Name
OMA
EggNOG
Inparanoid
Macaque
syndecan 1
Mouse
Rat
Dog
syndecan 1
Horse
syndecan 1
Publication Statistics
PubMed Score 2915.76
PubMed score by year
PubTator Score 1001.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title