Tbio SDC1 Syndecan-1

Protein Summary

Description

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P18827
• D6W523
• Q53QV0
• Q546D3
• Q96HB7
• SYND1

Gene Name

• SDC1

Ensembl ID

• ENST00000254351
• ENSP00000254351
• ENSG00000115884
• ENST00000381150
• ENSP00000370542

Symbol

• SDC
• SDC
• CD138
• SYND1
• syndecan

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
kinase perturbation	0.93
biological process	0.91
disease perturbation	0.87
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Syndecan-1

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Syndecan-1

Protein / Defense/immunity Protein / Syndecan-1

Protein / Cytoskeletal Protein / Syndecan-1

Protein / Cell Adhesion Molecule / Syndecan-1

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Syndecan-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2915.76   (req: < 5)

Gene RIFs: 356   (req: <= 3)

Antibodies: 1362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2915.76   (req: >= 5)

Gene RIFs: 356   (req: > 3)

Antibodies: 1362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0