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Tbio
SCYL3
Protein-associating with the carboxyl-terminal domain of ezrin

Protein Summary
Description
May play a role in regulating cell adhesion/migration complexes in migrating cells. This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367770
  • ENSP00000356744
  • ENSG00000000457
  • ENST00000367771
  • ENSP00000356745
  • ENST00000367772
  • ENSP00000356746

Symbol
  • PACE1
  • PACE1
  • PACE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
transcription factor binding site profile
0.86
virus perturbation
0.85
kinase perturbation
0.76
histone modification site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.999989829
p_ni:  0.000010171
Data Source:  BioPlex
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.999977319
p_ni:  0.000022303
p_wrong:  3.77e-7
Data Source:  BioPlex
JPH1
Tbio
Novelty:  0.00931679
p_int:  0.999924893
p_ni:  0.000075107
Data Source:  BioPlex
ARSF
Tbio
Family:  Enzyme
Novelty:  0.13109678
p_int:  0.99963385
p_ni:  0.00036615
Data Source:  BioPlex
WDR45B
Tbio
Novelty:  0.22407227
p_int:  0.999551075
p_ni:  0.000448925
Data Source:  BioPlex
SRBD1
Tbio
Novelty:  0.18931356
p_int:  0.999522943
p_ni:  0.000477057
Data Source:  BioPlex
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
p_int:  0.999073749
p_ni:  0.000926241
p_wrong:  1.1e-8
Score:  0.154
Data Source:  BioPlex,STRINGDB
VPS11
Tbio
Novelty:  0.00496411
p_int:  0.997692676
p_ni:  0.002307324
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.995183351
p_ni:  0.004816649
Data Source:  BioPlex
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
p_int:  0.995176973
p_ni:  0.004819752
p_wrong:  0.000003275
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
2
83.9
e-selectin measurement
1
1
1
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
83.9
e-selectin measurement
1
82.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SCY1 like pseudokinase 3
VGNC:8447
457502
Macaque
SCY1 like pseudokinase 3
701768
Mouse
MGI:1921385
240880
Rat
RGD:1308992
360866
Dog
SCY1 like pseudokinase 3
VGNC:45940
480077
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SCY1 like pseudokinase 3
Macaque
SCY1 like pseudokinase 3
Mouse
Rat
Dog
SCY1 like pseudokinase 3
Publication Statistics
PubMed Score 7.18
PubMed score by year
PubTator Score 3.08
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title