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Tbio
SCYL1
N-terminal kinase-like protein

Protein Summary
Description
Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652). Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270176
  • ENSP00000270176
  • ENSG00000142186
  • ENST00000420247
  • ENSP00000408192
  • ENST00000533862
  • ENSP00000437254

Symbol
  • CVAK90
  • GKLP
  • NTKL
  • TAPK
  • TEIF
  • TRAP
  • GKLP
  • NKTL
  • NTKL
  • P105
  • TAPK
  • TEIF
  • TRAP
  • HT019
  • SCAR21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
interacting protein
0.89
cellular component
0.8
histone modification site profile
0.8
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0