Tbio SCT Secretin

Protein Summary

Description

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach. This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P09683

Gene Name

• SCT

Ensembl ID

• ENST00000176195
• ENSP00000176195
• ENSG00000070031
• ENST00000622382
• ENSP00000483559
• ENSG00000274473

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.61
chemical	0.58
cell line	0.54
biological term	0.47
transcription factor perturbation	0.47

Protein Classes

DTO Classes

Secretin Receptor / Class B Secretin Like / Class B Secretin Like Gene / Growth Hormone Secreting Pituitary Adenoma / Secretin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1315.02   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1315.02   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0