Protein Summary
Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach. This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]
- ENST00000176195
- ENSP00000176195
- ENSG00000070031
- ENST00000622382
- ENSP00000483559
- ENSG00000274473
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.61 | ||
chemical | 0.58 | ||
cell line | 0.54 | ||
biological term | 0.47 | ||
transcription factor perturbation | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1263.99 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1263.99 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (180)
Nearest Tclin Targets
Pathways (23)
Reactome (7)
KEGG (3)
PathwayCommons (6)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Glucagon-type ligand receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Glucagon-type ligand receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
8 | 7 | 0 | 1.2 | 91.3 | ||||||
8 | 7 | 0 | 1.2 | 91.3 | ||||||
2 | 2 | 0 | 1.2 | 46.9 | ||||||
2 | 2 | 0 | 1.2 | 46.9 | ||||||
1 | 1 | 0 | 1.1 | 9.6 | ||||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 91.3 | |||||
0 | 1.2 | 91.3 | |||||
0 | 1.2 | 46.9 | |||||
0 | 1.2 | 46.9 | |||||
0 | 1.1 | 9.6 | |||||
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IDG Resources
Orthologs (3)
Publication Statistics
PubMed Score 1263.99
PubMed score by year
PubTator Score 988.74
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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