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Tbio
SCRN1
Secernin-1

Protein Summary
Description
Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242059
  • ENSP00000242059
  • ENSG00000136193
  • ENST00000409497
  • ENSP00000386872
  • ENST00000425819
  • ENSP00000414245
  • ENST00000426154
  • ENSP00000409068
  • ENST00000434476
  • ENSP00000388942

Symbol
  • KIAA0193
  • SES1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.84
PubMedID
0.69
microRNA
0.66
transcription factor
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.04   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.04   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
TAB2
Tbio
Family:  Enzyme
Novelty:  0.00635786
p_int:  0.999988538
p_ni:  0.000011462
Score:  0.189
Data Source:  BioPlex,STRINGDB
TAB1
Tchem
Family:  Kinase
Novelty:  0.00721424
p_int:  0.998797399
p_ni:  0.001202601
Score:  0.152
Data Source:  BioPlex,STRINGDB
CD3EAP
Tbio
Family:  Enzyme
Novelty:  0.04978272
p_int:  0.991121693
p_ni:  0.008051208
p_wrong:  0.000827099
Score:  0.187
Data Source:  BioPlex,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.989176713
p_ni:  0.010811116
p_wrong:  0.000012171
Score:  0.179
Data Source:  BioPlex,STRINGDB
CCDC85C
Tbio
Novelty:  0.30053883
p_int:  0.98683321
p_ni:  0.01316679
Score:  0.151
Data Source:  BioPlex,STRINGDB
DENND4A
Tbio
Novelty:  0.22983311
p_int:  0.947408445
p_ni:  0.003348433
p_wrong:  0.049243122
Score:  0.187
Data Source:  BioPlex,STRINGDB
CTU1
Tbio
Novelty:  0.04670058
p_int:  0.925048474
p_ni:  0.07495152
p_wrong:  6e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
POPDC3
Tbio
Novelty:  0.15787856
p_int:  0.899204123
p_ni:  0.100795876
p_wrong:  1e-9
Score:  0.387
Data Source:  BioPlex,STRINGDB
CCDC121
Tdark
Novelty:  1.80941324
p_int:  0.893074247
p_ni:  0.106925752
Score:  0.241
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.887452861
p_ni:  0.112547139
Score:  0.233
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
84.6
myeloid white cell count
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
84.6
myeloid white cell count
1
42.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secernin 1
VGNC:4501
463323
Macaque
secernin 1
696370
Mouse
MGI:1917188
69938
Rat
RGD:1560999
502776
Horse
secernin 1
VGNC:22751
100069716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secernin 1
Macaque
secernin 1
Mouse
Rat
Horse
secernin 1
Publication Statistics
PubMed Score 14.04
PubMed score by year
PubTator Score 25.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title