Tbio SCRN1 Secernin-1

Protein Summary

Description

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q12765
• A8K0E9
• B4DHM0
• B4DIP5
• C9JPG0
• Q25QX7
• Q8IWD1

Gene Name

• SCRN1

Ensembl ID

• ENST00000242059
• ENSP00000242059
• ENSG00000136193
• ENST00000409497
• ENSP00000386872
• ENST00000425819
• ENSP00000414245
• ENST00000426154
• ENSP00000409068
• ENST00000434476
• ENSP00000388942

Symbol

• KIAA0193
• SES1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.84
PubMedID	0.69
microRNA	0.66
transcription factor	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.56   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.56   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0