Protein Summary
Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
- ENST00000242059
- ENSP00000242059
- ENSG00000136193
- ENST00000409497
- ENSP00000386872
- ENST00000425819
- ENSP00000414245
- ENST00000426154
- ENSP00000409068
- ENST00000434476
- ENSP00000388942
- KIAA0193
- SES1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.99 | ||
transcription factor perturbation | 0.84 | ||
PubMedID | 0.69 | ||
microRNA | 0.66 | ||
transcription factor | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.04 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 164 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.04 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 164 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (38)
TAB2
Family: Enzyme
Novelty: 0.00635786
p_int: 0.999988538
p_ni: 0.000011462
Score: 0.189
Data Source: BioPlex,STRINGDB
TAB1
Family: Kinase
Novelty: 0.00721424
p_int: 0.998797399
p_ni: 0.001202601
Score: 0.152
Data Source: BioPlex,STRINGDB
CD3EAP
Family: Enzyme
Novelty: 0.04978272
p_int: 0.991121693
p_ni: 0.008051208
p_wrong: 0.000827099
Score: 0.187
Data Source: BioPlex,STRINGDB
MAP3K7
Family: Kinase
Novelty: 0.00540177
p_int: 0.989176713
p_ni: 0.010811116
p_wrong: 0.000012171
Score: 0.179
Data Source: BioPlex,STRINGDB
CCDC85C
Novelty: 0.30053883
p_int: 0.98683321
p_ni: 0.01316679
Score: 0.151
Data Source: BioPlex,STRINGDB
DENND4A
Novelty: 0.22983311
p_int: 0.947408445
p_ni: 0.003348433
p_wrong: 0.049243122
Score: 0.187
Data Source: BioPlex,STRINGDB
CTU1
Novelty: 0.04670058
p_int: 0.925048474
p_ni: 0.07495152
p_wrong: 6e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
POPDC3
Novelty: 0.15787856
p_int: 0.899204123
p_ni: 0.100795876
p_wrong: 1e-9
Score: 0.387
Data Source: BioPlex,STRINGDB
CCDC121
Novelty: 1.80941324
p_int: 0.893074247
p_ni: 0.106925752
Score: 0.241
Data Source: BioPlex,STRINGDB
VAPA
Novelty: 0.00169209
p_int: 0.887452861
p_ni: 0.112547139
Score: 0.233
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.6 | 84.6 | |||||
myeloid white cell count | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.6 | 84.6 | |||||
myeloid white cell count | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | secernin 1 | VGNC:4501 | 463323 | |||||
Macaque | secernin 1 | 696370 | ||||||
Mouse | MGI:1917188 | 69938 | ||||||
Rat | RGD:1560999 | 502776 | ||||||
Horse | secernin 1 | VGNC:22751 | 100069716 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | secernin 1 | |||||
Macaque | secernin 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | secernin 1 | |||||
Publication Statistics
PubMed Score 14.04
PubMed score by year
PubTator Score 25.72
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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