Tbio SCRN1 Secernin-1

Protein Summary

Description

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q12765
• A8K0E9
• B4DHM0
• B4DIP5
• C9JPG0
• Q25QX7
• Q8IWD1

Gene Name

• SCRN1

Ensembl ID

• ENST00000242059
• ENSP00000242059
• ENSG00000136193
• ENST00000409497
• ENSP00000386872
• ENST00000425819
• ENSP00000414245
• ENST00000426154
• ENSP00000409068
• ENST00000434476
• ENSP00000388942

Symbol

• KIAA0193
• SES1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.84
PubMedID	0.69
microRNA	0.66
transcription factor	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.04   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.04   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (38)

Explore Interacting Targets

1 – 10 of 38

• See Interactions on String-DB

TAB2

Tbio

Family:  Enzyme

Novelty:  0.00635786

p_int:  0.999988538

p_ni:  0.000011462

Score:  0.189

Data Source:  BioPlex,STRINGDB

TAB1

Tchem

Family:  Kinase

Novelty:  0.00721424

p_int:  0.998797399

p_ni:  0.001202601

Score:  0.152

Data Source:  BioPlex,STRINGDB

CD3EAP

Tbio

Family:  Enzyme

Novelty:  0.04978272

p_int:  0.991121693

p_ni:  0.008051208

p_wrong:  0.000827099

Score:  0.187

Data Source:  BioPlex,STRINGDB

MAP3K7

Tchem

Family:  Kinase

Novelty:  0.00540177

p_int:  0.989176713

p_ni:  0.010811116

p_wrong:  0.000012171

Score:  0.179

Data Source:  BioPlex,STRINGDB

CCDC85C

Tbio

Novelty:  0.30053883

p_int:  0.98683321

p_ni:  0.01316679

Score:  0.151

Data Source:  BioPlex,STRINGDB

DENND4A

Tbio

Novelty:  0.22983311

p_int:  0.947408445

p_ni:  0.003348433

p_wrong:  0.049243122

Score:  0.187

Data Source:  BioPlex,STRINGDB

CTU1

Tbio

Novelty:  0.04670058

p_int:  0.925048474

p_ni:  0.07495152

p_wrong:  6e-9

Score:  0.181

Data Source:  BioPlex,STRINGDB

POPDC3

Tbio

Novelty:  0.15787856

p_int:  0.899204123

p_ni:  0.100795876

p_wrong:  1e-9

Score:  0.387

Data Source:  BioPlex,STRINGDB

CCDC121

Tdark

Novelty:  1.80941324

p_int:  0.893074247

p_ni:  0.106925752

Score:  0.241

Data Source:  BioPlex,STRINGDB

VAPA

Tbio

Novelty:  0.00169209

p_int:  0.887452861

p_ni:  0.112547139

Score:  0.233

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (3)

Processes (1)

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10

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GO Term	Evidence	Assigned by
dipeptidase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriasis	EFO_0000676	1	1	0	1.6	84.6
myeloid white cell count	EFO_0007988	1	1	1		42.3

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Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriasis	EFO_0000676	0	1.6	84.6
myeloid white cell count	EFO_0007988	1		42.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Exocytosis
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
myeloid white cell count
psoriasis

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	secernin 1	VGNC:4501	463323
Macaque	secernin 1		696370
Mouse	secernin 1	MGI:1917188	69938
Rat	secernin 1	RGD:1560999	502776
Horse	secernin 1	VGNC:22751	100069716

Species	Name	OMA	EggNOG	Inparanoid
Chimp	secernin 1
Macaque	secernin 1
Mouse	secernin 1
Rat	secernin 1
Horse	secernin 1

Publication Statistics

PubMed Score 14.04

PubMed score by year

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PubTator Score 25.72

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (8)

Items per page:

10

0 of 0

PMID	Year	Title