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Tbio
SCOC
Short coiled-coil protein

Protein Summary
Description
Positive regulator of amino acid starvation-induced autophagy. This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338517
  • ENSP00000345262
  • ENSG00000153130
  • ENST00000394203
  • ENSP00000377753
  • ENST00000394205
  • ENSP00000377755
  • ENST00000506597
  • ENSP00000426649
  • ENST00000608372
  • ENSP00000477352
  • ENST00000614192
  • ENSP00000477812

Symbol
  • SCOCO
  • SCOCO
  • UNC-69
  • HRIHFB2072
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.75
transcription factor perturbation
0.68
disease perturbation
0.62
tissue sample
0.62
cellular component
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
EURL
Tbio
Novelty:  0.05459877
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.297
Data Source:  BioPlex,STRINGDB
SCHIP1
Tbio
Novelty:  0.0765945
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.297
Data Source:  BioPlex,STRINGDB
FEZ2
Tbio
Novelty:  0.1716508
p_int:  0.999999994
p_ni:  6e-9
Score:  0.948
Data Source:  BioPlex,STRINGDB
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.999999939
p_ni:  6.1e-8
Score:  0.958
Data Source:  BioPlex,STRINGDB
TBC1D30
Tbio
Novelty:  0.97335151
p_int:  0.999999938
p_ni:  4.1e-8
p_wrong:  2.1e-8
Score:  0.297
Data Source:  BioPlex,STRINGDB
HEATR5A
Tdark
Novelty:  4.84461801
p_int:  0.999999487
p_ni:  2.2e-8
p_wrong:  4.91e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.999991901
p_ni:  0.000008099
Data Source:  BioPlex
GCC1
Tbio
Novelty:  0.0844824
p_int:  0.999971831
p_ni:  0.000028163
p_wrong:  6e-9
Score:  0.381
Data Source:  BioPlex,STRINGDB
NRBF2
Tbio
Novelty:  0.02432243
p_int:  0.999896333
p_ni:  0.000103653
p_wrong:  1.4e-8
Score:  0.327
Data Source:  BioPlex,STRINGDB
LUZP1
Tbio
Novelty:  0.14991475
p_int:  0.999840961
p_ni:  0.000159034
p_wrong:  5e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

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1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
short coiled-coil protein
VGNC:681
737312
Mouse
MGI:1927654
56367
Rat
RGD:1311860
364981
Dog
short coiled-coil protein
VGNC:54827
606862
Cow
short coiled-coil protein
VGNC:34360
504257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
short coiled-coil protein
Mouse
Rat
Dog
short coiled-coil protein
Cow
short coiled-coil protein
Publication Statistics
PubMed Score 19.70
PubMed score by year
PubTator Score 4.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title