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Tclin
SCNN1G
Amiloride-sensitive sodium channel subunit gamma

Protein Summary
Description
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300061
  • ENSP00000300061
  • ENSG00000166828

Symbol
  • PHA1
  • BESC3
  • ENaCg
  • LDLS2
  • SCNEG
  • ENaCgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
gene perturbation
0.76
cellular component
0.65
histone modification site profile
0.62
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.98   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.98   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
Score:  0.991
Data Source:  STRINGDB
SGK1
Tchem
Family:  Kinase
Novelty:  0.00155681
Score:  0.972
Data Source:  STRINGDB
WNK4
Tbio
Family:  Kinase
Novelty:  0.00795905
Score:  0.967
Data Source:  STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
Score:  0.958
Data Source:  STRINGDB
SCNN1B
Tclin
Family:  IC
Novelty:  0.01281284
Score:  0.957
Data Source:  Reactome,STRINGDB
SCNN1A
Tclin
Family:  IC
Novelty:  0.00900102
Score:  0.949
Data Source:  Reactome,STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
Score:  0.945
Data Source:  Reactome,STRINGDB
WNK3
Tchem
Family:  Kinase
Novelty:  0.03382701
Score:  0.938
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.931
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium channel epithelial 1 gamma subunit
VGNC:9103
467925
Macaque
sodium channel epithelial 1 gamma subunit
699971
Mouse
MGI:104695
20278
Rat
RGD:3641
24768
Dog
sodium channel epithelial 1 gamma subunit
VGNC:45928
489973
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium channel epithelial 1 gamma subunit
Macaque
sodium channel epithelial 1 gamma subunit
Mouse
Rat
Dog
sodium channel epithelial 1 gamma subunit
Publication Statistics
PubMed Score 157.98
PubMed score by year
PubTator Score 125.55
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title