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Tbio
SCNN1D
Amiloride-sensitive sodium channel subunit delta

Protein Summary
Description
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325425
  • ENSP00000321594
  • ENSG00000162572
  • ENST00000338555
  • ENSP00000339504
  • ENST00000400928
  • ENSP00000383717

Symbol
  • DNACH
  • ENaCd
  • SCNED
  • dNaCh
  • ENaCdelta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
virus perturbation
0.59
tissue sample
0.58
cellular component
0.53
tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
STX11
Tbio
Novelty:  0.01670743
p_int:  0.999999055
p_ni:  9.45e-7
Data Source:  BioPlex
ABHD16A
Tchem
Family:  Enzyme
Novelty:  0.04797219
p_int:  0.999989121
p_ni:  0.000010607
p_wrong:  2.72e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
MTFR2
Tbio
Novelty:  0.20272025
p_int:  0.999943084
p_ni:  0.000056914
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
TAP2
Tbio
Novelty:  0.0390555
p_int:  0.998518901
p_ni:  0.001353559
p_wrong:  0.000127541
Score:  0.209
Data Source:  BioPlex,STRINGDB
DPY19L1
Tdark
Family:  Enzyme
Novelty:  0.34765717
p_int:  0.992353478
p_ni:  0.004468647
p_wrong:  0.003177876
Data Source:  BioPlex
CLSTN3
Tbio
Novelty:  0.10438143
p_int:  0.991902644
p_ni:  0.008097356
Score:  0.295
Data Source:  BioPlex,STRINGDB
P10314
Tbio
Novelty:  0.00270731
p_int:  0.990930152
p_ni:  0.009069848
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.98655296
p_ni:  0.013430323
p_wrong:  0.000016716
Score:  0.17
Data Source:  BioPlex,STRINGDB
CFAP74
Tdark
Novelty:  0.37177561
p_int:  0.985974846
p_ni:  0.013750201
p_wrong:  0.000274953
Score:  0.25
Data Source:  BioPlex,STRINGDB
LRRC3
Tdark
Novelty:  0.13484671
p_int:  0.974907735
p_ni:  0.019007983
p_wrong:  0.006084282
Score:  0.17
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
intraocular pressure measurement
1
2
2
52.7
1
1
0
1.1
35
hair color
1
1
0
1.1
8.6
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
intraocular pressure measurement
2
52.7
0
1.1
35
hair color
0
1.1
8.6
heel bone mineral density
1
6.7
Find similar targets by:
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium channel epithelial 1 delta subunit
VGNC:53219
450189
Dog
sodium channel epithelial 1 delta subunit
VGNC:45927
489598
Horse
sodium channel epithelial 1 delta subunit
VGNC:50761
100066014
Cow
sodium channel epithelial 1 delta subunit
VGNC:34357
528813
Xenopus
sodium channel, non voltage gated 1 delta subunit
XB-GENE-991876
100496702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium channel epithelial 1 delta subunit
Dog
sodium channel epithelial 1 delta subunit
Horse
sodium channel epithelial 1 delta subunit
Cow
sodium channel epithelial 1 delta subunit
Xenopus
sodium channel, non voltage gated 1 delta subunit
Publication Statistics
PubMed Score 15.33
PubMed score by year
PubTator Score 14.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title