Tbio SCNN1D Amiloride-sensitive sodium channel subunit delta

Protein Summary

Description

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Uniprot Accession IDs

• P51172
• A9Z1X6
• B1PS44
• Q08AQ3
• Q09HT0
• Q5T7L3
• Q8NA24

Gene Name

• SCNN1D

Ensembl ID

• ENST00000325425
• ENSP00000321594
• ENSG00000162572
• ENST00000338555
• ENSP00000339504
• ENST00000400928
• ENSP00000383717

Symbol

• DNACH
• ENaCd
• SCNED
• dNaCh
• ENaCdelta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
virus perturbation	0.59
tissue sample	0.58
cellular component	0.53
tissue	0.47

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Amiloride-sensitive Sodium Channel Subunit Delta

DTO Classes

Protein / Ion Channel / Amiloride-sensitive Sodium Channel Family / Scnn1d Subfamily / Amiloride-sensitive Sodium Channel Subunit Delta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.78   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.78   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0