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Tclin
SCNN1A
Amiloride-sensitive sodium channel subunit alpha

Protein Summary
Description
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript var ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228916
  • ENSP00000228916
  • ENSG00000111319
  • ENST00000360168
  • ENSP00000353292
  • ENST00000543768
  • ENSP00000438739

Symbol
  • SCNN1
  • BESC2
  • ENaCa
  • SCNEA
  • SCNN1
  • LIDLS3
  • ENaCalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
molecular function
0.88
cellular component
0.82
disease
0.81
small molecule perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.71   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.71   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (110)
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
Score:  0.991
Data Source:  STRINGDB
SGK1
Tchem
Family:  Kinase
Novelty:  0.00155681
Score:  0.975
Data Source:  STRINGDB
WNK4
Tbio
Family:  Kinase
Novelty:  0.00795905
Score:  0.961
Data Source:  STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
Score:  0.957
Data Source:  STRINGDB
SCNN1B
Tclin
Family:  IC
Novelty:  0.01281284
Score:  0.954
Data Source:  Reactome,STRINGDB
SCNN1G
Tclin
Family:  IC
Novelty:  0.00689941
Score:  0.949
Data Source:  Reactome,STRINGDB
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
Score:  0.948
Data Source:  STRINGDB
WNK2
Tchem
Family:  Kinase
Novelty:  0.05450998
Score:  0.943
Data Source:  STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
Score:  0.941
Data Source:  STRINGDB
WNK3
Tchem
Family:  Kinase
Novelty:  0.03382701
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
6
98
5
4
0
1.1
95.8
monocyte count
2
3
3
95.8
platelet crit
2
6
6
95.6
neutrophil percentage of leukocytes
2
3
3
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
6
98
0
1.1
95.8
monocyte count
3
95.8
platelet crit
6
95.6
neutrophil percentage of leukocytes
3
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium channel epithelial 1 alpha subunit
VGNC:13442
451776
Macaque
sodium channel epithelial 1 alpha subunit
712476
Mouse
MGI:101782
20276
Rat
RGD:3639
25122
Dog
sodium channel epithelial 1 alpha subunit
VGNC:45925
403650
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium channel epithelial 1 alpha subunit
Macaque
sodium channel epithelial 1 alpha subunit
Mouse
Rat
Dog
sodium channel epithelial 1 alpha subunit
Publication Statistics
PubMed Score 109.71
PubMed score by year
PubTator Score 101.84
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title