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Tbio
SCNM1
Sodium channel modifier 1

Protein Summary
Description
Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. This locus represents naturally occurring read-through transcription between the neighboring TNFAIP8L2 (tumor necrosis factor, alpha-induced protein 8-like 2) and SCNM1 (sodium channel modifier 1) genes on chromosome 1. The protein-coding read-through transcript variant encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is shorter due to alternate exon use relative to the downstream gene. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368902
  • ENSP00000357898
  • ENSG00000163156
  • ENST00000368905
  • ENSP00000357901
  • ENST00000602841
  • ENSP00000473282

Symbol
  • SCNM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
virus perturbation
0.92
histone modification site profile
0.9
disease perturbation
0.87
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.7   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.7   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
RSAD2
Tbio
Novelty:  0.0056473
p_int:  0.99987424
p_ni:  0.000124912
p_wrong:  8.48e-7
Score:  0.403
Data Source:  BioPlex,STRINGDB
SPIN1
Tchem
Novelty:  0.00889909
p_int:  0.999807211
p_ni:  0.000192405
p_wrong:  3.84e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.999795508
p_ni:  0.000204492
Data Source:  BioPlex
FHL5
Tbio
Novelty:  0.27618006
p_int:  0.99936427
p_ni:  0.000635011
p_wrong:  7.19e-7
Data Source:  BioPlex
SNX3
Tbio
Novelty:  0.02703152
p_int:  0.982756926
p_ni:  0.017240436
p_wrong:  0.000002637
Score:  0.165
Data Source:  BioPlex,STRINGDB
PMVK
Tchem
Family:  Enzyme
Novelty:  0.00468598
p_int:  0.98154327
p_ni:  0.018294338
p_wrong:  0.000162392
Score:  0.226
Data Source:  BioPlex,STRINGDB
DOHH
Tbio
Family:  Enzyme
Novelty:  0.02313651
p_int:  0.833389895
p_ni:  0.166607223
p_wrong:  0.000002882
Score:  0.214
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
Score:  0.94
Data Source:  STRINGDB
SCN8A
Tclin
Family:  IC
Novelty:  0.00203805
Score:  0.757
Data Source:  STRINGDB
SCN7A
Tclin
Family:  IC
Novelty:  0.05343818
Score:  0.717
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
78.9
1
1
0
100
76.6
monocyte percentage of leukocytes
1
1
1
60.5
vitamin D measurement
1
1
1
59
body height
2
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
78.9
0
100
76.6
monocyte percentage of leukocytes
1
60.5
vitamin D measurement
1
59
body height
2
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium channel modifier 1
VGNC:10992
457285
Macaque
sodium channel modifier 1
709922
Mouse
MGI:1341284
69269
Rat
RGD:1308968
310662
Dog
sodium channel modifier 1
VGNC:49785
100683396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium channel modifier 1
Macaque
sodium channel modifier 1
Mouse
Rat
Dog
sodium channel modifier 1
Publication Statistics
PubMed Score 5.70
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title