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Tclin
SCN9A
Sodium channel protein type 9 subunit alpha

Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303354
  • ENSP00000304748
  • ENSG00000169432
  • ENST00000409435
  • ENSP00000386330
  • ENST00000409672
  • ENSP00000386306
  • ENST00000642356
  • ENSP00000495601
  • ENST00000645907
  • ENSP00000495983

Symbol
  • NENA
  • PN1
  • ETHA
  • NENA
  • SFNP
  • FEB3B
  • NE-NA
  • GEFSP7
  • HSAN2D
  • Nav1.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
biological term
0.84
virus perturbation
0.83
kinase perturbation
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 865.14   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 865.14   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5455
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20