SCN9A
Sodium channel protein type 9 subunit alpha
Protein Summary
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
- ENST00000303354
- ENSP00000304748
- ENSG00000169432
- ENST00000409435
- ENSP00000386330
- ENST00000409672
- ENSP00000386306
- ENST00000642356
- ENSP00000495601
- ENST00000645907
- ENSP00000495983
- NENA
- PN1
- ETHA
- NENA
- SFNP
- FEB3B
- NE-NA
- GEFSP7
- HSAN2D
- Nav1.7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
molecular function | 0.9 | ||
biological term | 0.84 | ||
virus perturbation | 0.83 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 865.14 (req: < 5)
Gene RIFs: 173 (req: <= 3)
Antibodies: 452 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 865.14 (req: >= 5)
Gene RIFs: 173 (req: > 3)
Antibodies: 452 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5455
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 20