Tbio SCN3B Sodium channel subunit beta-3

Protein Summary

Description

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NY72
• A5H1I5
• Q17RL3
• Q9ULR2

Gene Name

• SCN3B

Ensembl ID

• ENST00000299333
• ENSP00000299333
• ENSG00000166257
• ENST00000392770
• ENSP00000376523
• ENST00000530277
• ENSP00000432785

Symbol

• KIAA1158
• SCNB3
• ATFB16
• BRGDA7
• HSA243396

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
molecular function	0.91
protein domain	0.85
histone modification site profile	0.73
biological process	0.71

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Sodium Channel Subunit Beta-3

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Sodium Channel Subunit Beta-3

DTO Classes

Protein / Ion Channel / Sodium Channel Auxiliary Subunit 1-4 (Sca-) Family / Scn3b Family / Sodium Channel Subunit Beta-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.15   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.15   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0