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Tbio
SCN2B
Sodium channel subunit beta-2

Protein Summary
Description
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278947
  • ENSP00000278947
  • ENSG00000149575

Symbol
  • ATFB14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.85
microRNA
0.72
PubMedID
0.63
biological process
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.7   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.7   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
RNF213
Tbio
Family:  Enzyme
Novelty:  0.00588778
p_int:  0.999999794
p_ni:  2.06e-7
Data Source:  BioPlex
RBFA
Tbio
Novelty:  0.1061138
p_int:  0.999993106
p_ni:  0.000005269
p_wrong:  0.000001625
Data Source:  BioPlex
RRP1
Tbio
Novelty:  0.12984245
p_int:  0.999986779
p_ni:  0.000013221
Data Source:  BioPlex
SLC25A51
Tbio
Family:  Transporter
Novelty:  0.21568087
p_int:  0.99997575
p_ni:  0.000024246
p_wrong:  4e-9
Data Source:  BioPlex
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.999954521
p_ni:  0.000045479
Data Source:  BioPlex
FOCAD
Tbio
Novelty:  0.14213271
p_int:  0.999952093
p_ni:  0.000036578
p_wrong:  0.00001133
Score:  0.186
Data Source:  BioPlex,STRINGDB
ORC5
Tbio
Novelty:  0.02264865
p_int:  0.999930718
p_ni:  0.000069278
p_wrong:  4e-9
Data Source:  BioPlex
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
p_int:  0.999647099
p_ni:  0.000352901
p_wrong:  1e-9
Data Source:  BioPlex
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.999482488
p_ni:  0.000517512
Data Source:  BioPlex
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
p_int:  0.999467125
p_ni:  0.000473064
p_wrong:  0.000059811
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
5
94.9
leukocyte count
2
2
3
91.1
myeloid white cell count
2
1
2
84.1
monocyte count
2
1
2
69.3
granulocyte count
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
94.9
leukocyte count
3
91.1
myeloid white cell count
2
84.1
monocyte count
2
69.3
granulocyte count
1
62.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sodium voltage-gated channel beta subunit 2
678698
Mouse
MGI:106921
72821
Rat
RGD:3633
25349
Dog
sodium voltage-gated channel beta subunit 2
VGNC:45917
403485
Horse
sodium voltage-gated channel beta subunit 2
VGNC:22735
100062848
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sodium voltage-gated channel beta subunit 2
Mouse
Rat
Dog
sodium voltage-gated channel beta subunit 2
Horse
sodium voltage-gated channel beta subunit 2
Publication Statistics
PubMed Score 23.70
PubMed score by year
PubTator Score 11.25
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title