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Tclin
SCN2A
Sodium channel protein type 2 subunit alpha

Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283256
  • ENSP00000283256
  • ENSG00000136531
  • ENST00000375427
  • ENSP00000364576
  • ENST00000375437
  • ENSP00000364586
  • ENST00000631182
  • ENSP00000486885
  • ENST00000636071
  • ENSP00000490107
  • ENST00000637266
  • ENSP00000490866

Symbol
  • NAC2
  • SCN2A1
  • SCN2A2
  • HBA
  • NAC2
  • BFIC3
  • BFIS3
  • BFNIS
  • HBSCI
  • EIEE11
  • HBSCII
  • Nav1.2
  • SCN2A1
  • SCN2A2
  • Na(v)1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
virus perturbation
0.79
molecular function
0.76
gene perturbation
0.66
transcription factor
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.68   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.68   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 126
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 26