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Tclin
SCN1A
Sodium channel protein type 1 subunit alpha

Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli. Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303395
  • ENSP00000303540
  • ENSG00000144285
  • ENST00000375405
  • ENSP00000364554
  • ENST00000409050
  • ENSP00000386312
  • ENST00000423058
  • ENSP00000407030
  • ENST00000635750
  • ENSP00000490799
  • ENST00000637988
  • ENSP00000490780

Symbol
  • NAC1
  • SCN1
  • FEB3
  • FHM3
  • NAC1
  • SCN1
  • SMEI
  • EIEE6
  • FEB3A
  • HBSCI
  • GEFSP2
  • Nav1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
protein domain
0.92
cell type or tissue
0.79
molecular function
0.76
cell line
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.1   (req: < 5)
Gene RIFs: 270   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1155.1   (req: >= 5)
Gene RIFs: 270   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 50
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 23