SCLY
Selenocysteine lyase
Protein Summary
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
- ENST00000409736
- ENSP00000387162
- ENSG00000132330
- SCL
- SCL
- hSCL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.66 | ||
tissue sample | 0.65 | ||
virus perturbation | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.59 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 112 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.59 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 112 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (9)
Reactome (4)
KEGG (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of ingested SeMet, Sec, MeSec into H2Se | ||||
Reactome | Selenoamino acid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of ingested SeMet, Sec, MeSec into H2Se | ||||
Selenoamino acid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 2 | 1 | 2 | 81.5 | |||||
red blood cell distribution width | 3 | 2 | 3 | 79.2 | |||||
hemoglobin measurement | 2 | 1 | 2 | 70.8 | |||||
mathematical ability | 3 | 2 | 3 | 68.4 | |||||
transferrin saturation measurement | 1 | 1 | 1 | 55.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 2 | 81.5 | |||||
red blood cell distribution width | 3 | 79.2 | |||||
hemoglobin measurement | 2 | 70.8 | |||||
mathematical ability | 3 | 68.4 | |||||
transferrin saturation measurement | 1 | 55.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | selenocysteine lyase | VGNC:14172 | 460055 | |||||
Macaque | selenocysteine lyase | 695511 | ||||||
Mouse | MGI:1355310 | 50880 | ||||||
Rat | RGD:1359514 | 363285 | ||||||
Dog | selenocysteine lyase | 477422 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | selenocysteine lyase | |||||
Macaque | selenocysteine lyase | |||||
Mouse | ||||||
Rat | ||||||
Dog | selenocysteine lyase | |||||
Publication Statistics
PubMed Score 23.59
PubMed score by year
PubTator Score 64.95
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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