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Tbio
SCGN
Secretagogin

Protein Summary
Description
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377961
  • ENSP00000367197
  • ENSG00000079689

Symbol
  • SECRET
  • SEGN
  • CALBL
  • SECRET
  • setagin
  • DJ501N12.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
trait
0.61
PubMedID
0.59
gene perturbation
0.58
tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.67   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.67   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
AGGF1
Tbio
Novelty:  0.02757407
p_int:  0.999998938
p_ni:  0.000001062
Data Source:  BioPlex
RAVER1
Tbio
Novelty:  0.08620158
p_int:  0.999994446
p_ni:  0.000005554
Score:  0.171
Data Source:  BioPlex,STRINGDB
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
p_int:  0.99998801
p_ni:  0.00001199
Score:  0.289
Data Source:  BioPlex,STRINGDB
KIF14
Tbio
Novelty:  0.02313641
p_int:  0.999979457
p_ni:  0.000020543
Score:  0.198
Data Source:  BioPlex,STRINGDB
DOC2A
Tbio
Novelty:  0.07489914
p_int:  0.999935279
p_ni:  0.000064721
Score:  0.248
Data Source:  BioPlex,STRINGDB
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.999787334
p_ni:  0.000191702
p_wrong:  0.000020964
Score:  0.258
Data Source:  BioPlex,STRINGDB
NBR1
Tbio
Novelty:  0.00893066
p_int:  0.999693375
p_ni:  0.000237374
p_wrong:  0.000069251
Score:  0.295
Data Source:  BioPlex,STRINGDB
GOLGB1
Tbio
Novelty:  0.00943584
p_int:  0.999674669
p_ni:  0.000325331
Score:  0.19
Data Source:  BioPlex,STRINGDB
ATF2
Tbio
Family:  TF
Novelty:  0.00457832
p_int:  0.998657253
p_ni:  0.000456107
p_wrong:  0.00088664
Score:  0.196
Data Source:  BioPlex,STRINGDB
OPA1
Tchem
Novelty:  0.0031868
p_int:  0.998570777
p_ni:  0.001429223
Score:  0.202
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
2
4
94
platelet count
2
2
2
92.1
uric acid measurement
3
3
3
90.5
urinary metabolite measurement
1
2
2
90.2
liver iron measurement
1
1
1
87.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
94
platelet count
2
92.1
uric acid measurement
3
90.5
urinary metabolite measurement
2
90.2
liver iron measurement
1
87.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretagogin, EF-hand calcium binding protein
VGNC:3695
462485
Macaque
secretagogin, EF-hand calcium binding protein
694072
Mouse
MGI:2384873
214189
Rat
RGD:1303281
306942
Dog
secretagogin, EF-hand calcium binding protein
VGNC:45909
610954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretagogin, EF-hand calcium binding protein
Macaque
secretagogin, EF-hand calcium binding protein
Mouse
Rat
Dog
secretagogin, EF-hand calcium binding protein
Publication Statistics
PubMed Score 91.67
PubMed score by year
PubTator Score 44.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title