Tbio SCGB2A1 Mammaglobin-B

Protein Summary

Description

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Uniprot Accession IDs

• O75556

Gene Name

• SCGB2A1

Ensembl ID

• ENST00000244930
• ENSP00000244930
• ENSG00000124939

Symbol

• LIPHC
• MGB2
• UGB3
• LPHC
• LPNC
• MGB2
• UGB3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.56
small molecule perturbation	0.54
disease	0.48
chemical	0.44
biological term	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.03   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.03   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (99)

Explore Interacting Targets

1 – 10 of 99

• See Interactions on String-DB

DDX31

Tbio

Family:  Enzyme

Novelty:  2.84646195

p_int:  0.999999115

p_ni:  8.76e-7

p_wrong:  9e-9

Data Source:  BioPlex

PCYOX1L

Tdark

Family:  Enzyme

Novelty:  1.25398886

p_int:  0.999997965

p_ni:  0.000002035

Data Source:  BioPlex

HBM

Tdark

Novelty:  0.02658671

p_int:  0.999995207

p_ni:  0.000004791

p_wrong:  2e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

PLA2G15

Tbio

Family:  Enzyme

Novelty:  0.01546393

p_int:  0.999989839

p_ni:  0.00000301

p_wrong:  0.000007151

Data Source:  BioPlex

GLB1L

Tdark

Family:  Enzyme

Novelty:  0.43027328

p_int:  0.999975952

p_ni:  0.00002404

p_wrong:  8e-9

Data Source:  BioPlex

CCDC148

Tdark

Novelty:  2.81805259

p_int:  0.999946192

p_ni:  0.000050606

p_wrong:  0.000003202

Score:  0.234

Data Source:  BioPlex,STRINGDB

SLC27A2

Tbio

Family:  Transporter

Novelty:  0.01436035

p_int:  0.999926282

p_ni:  0.000073718

Data Source:  BioPlex

LARGE1

Tbio

Family:  Enzyme

Novelty:  0.02518701

p_int:  0.999581079

p_ni:  0.000418916

p_wrong:  6e-9

Data Source:  BioPlex

DAAM2

Tbio

Novelty:  0.07318127

p_int:  0.999404734

p_ni:  0.000595259

p_wrong:  7e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

EXT1

Tbio

Family:  Enzyme

Novelty:  0.00355951

p_int:  0.999201732

p_ni:  0.000798268

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

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GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	2	2	1	1.1	54.2
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		35
ovarian carcinoma	EFO_0001075	1	1	1		33.1
breast carcinoma	EFO_0000305	1	1	1		33.1
gamma-linolenic acid measurement	EFO_0007762	1	1	1		6.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	1	1.1	54.2
sex hormone-binding globulin measurement	EFO_0004696	2		35
ovarian carcinoma	EFO_0001075	1		33.1
breast carcinoma	EFO_0000305	1		33.1
gamma-linolenic acid measurement	EFO_0007762	1		6.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

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Complete proteome
Direct protein sequencing
Glycoprotein
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist-hip ratio
breast carcinoma
gamma-linolenic acid measurement
ovarian carcinoma
prostate carcinoma
sex hormone-binding globulin measurement
waist-hip ratio

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	secretoglobin family 2A member 1	VGNC:6541	451249
Mouse	secretoglobin, family 2A, member 2	MGI:3780828	102639117
Rat	secretoglobin, family 2A, member 1	RGD:735031	361725
Dog	mammaglobin-A		612244
Horse	mammaglobin-B-like		100629936

Species	Name	OMA	EggNOG	Inparanoid
Chimp	secretoglobin family 2A member 1
Mouse	secretoglobin, family 2A, member 2
Rat	secretoglobin, family 2A, member 1
Dog	mammaglobin-A
Horse	mammaglobin-B-like

Publication Statistics

PubMed Score 57.03

PubMed score by year

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PubTator Score 208.51

PubTator score by year

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Related Publications

Text Mined References (32)

GeneRif Annotations (17)

Items per page:

10

0 of 0

PMID	Year	Title