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Tbio
SCGB1D1
Secretoglobin family 1D member 1

Protein Summary
Description
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones. The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene product represents one component of a heterodimeric molecule present in human tears whose elution profile is consistent with prostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15, this sequence appears to be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306238
  • ENSP00000303070
  • ENSG00000168515

Symbol
  • LIPHA
  • LPNA
  • LIPA
  • LPHA
  • LPNA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
chemical
0.41
protein complex
0.4
disease
0.36
cell line
0.35


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.53   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.53   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
LIFR
Tbio
Novelty:  0.00514085
p_int:  0.999998452
p_ni:  0.000001519
p_wrong:  2.8e-8
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.999751952
p_ni:  0.000248048
Data Source:  BioPlex
SEMA4D
Tbio
Novelty:  0.0043592
p_int:  0.999743484
p_ni:  0.000217704
p_wrong:  0.000038812
Data Source:  BioPlex
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.999717413
p_ni:  0.000282587
Data Source:  BioPlex
ITGA3
Tchem
Novelty:  0.00505981
p_int:  0.999657411
p_ni:  0.0002249
p_wrong:  0.000117689
Score:  0.173
Data Source:  BioPlex,STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.999589712
p_ni:  0.000410288
Data Source:  BioPlex
LEPR
Tclin
Novelty:  0.00070587
p_int:  0.999442875
p_ni:  0.000139924
p_wrong:  0.000417201
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.999413919
p_ni:  0.000586081
Data Source:  BioPlex
SEL1L3
Tdark
Novelty:  0.62775736
p_int:  0.998653292
p_ni:  0.001346644
p_wrong:  6.4e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
CLSTN1
Tbio
Novelty:  0.04056624
p_int:  0.998563916
p_ni:  0.001436084
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
54.2
sex hormone-binding globulin measurement
2
1
2
35
1
1
1
33.1
1
1
1
33.1
gamma-linolenic acid measurement
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
54.2
sex hormone-binding globulin measurement
2
35
1
33.1
1
33.1
gamma-linolenic acid measurement
1
6.2
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretoglobin family 1D member 1
VGNC:6543
739687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretoglobin family 1D member 1
Publication Statistics
PubMed Score 22.53
PubMed score by year
PubTator Score 23.57
PubTator score by year
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Related Publications
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PMID
Year
Title