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Tbio
SCG5
Neuroendocrine protein 7B2

Protein Summary
Description
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300175
  • ENSP00000300175
  • ENSG00000166922
  • ENST00000413748
  • ENSP00000388560
  • ENST00000614359
  • ENSP00000482615
  • ENSG00000277614
  • ENST00000632219
  • ENSP00000488109
  • ENSG00000281931
  • ENST00000632674
  • ENSP00000488509

Symbol
  • SGNE1
  • 7B2
  • SgV
  • P7B2
  • SGNE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
molecular function
0.86
PubMedID
0.81
small molecule perturbation
0.77
phenotype
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.99   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.99   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
CSH2
Tbio
Novelty:  0.0009706
p_int:  0.999957565
p_ni:  0.000042435
Score:  0.712
Data Source:  BioPlex,STRINGDB
PCSK2
Tchem
Family:  Enzyme
Novelty:  0.00611421
Score:  0.994
Data Source:  STRINGDB
CHGB
Tbio
Novelty:  0.00484507
Score:  0.845
Data Source:  STRINGDB
SCG2
Tbio
Novelty:  0.00389492
Score:  0.844
Data Source:  STRINGDB
SCG3
Tbio
Novelty:  0.02153066
Score:  0.831
Data Source:  STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
Score:  0.8
Data Source:  STRINGDB
SBSN
Tbio
Novelty:  0.05105712
Score:  0.755
Data Source:  STRINGDB
PCSK1N
Tbio
Novelty:  0.02656799
Score:  0.747
Data Source:  STRINGDB
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
Score:  0.731
Data Source:  STRINGDB
VGF
Tbio
Novelty:  0.00521876
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (201)
Items per page:
1 – 5 of 201
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
0
1.1
97
8
7
0
1.1
97
8
7
0
1.1
97
1
4
0
1.1
94.8
1
4
0
1.1
94.8
Items per page:
1 – 5 of 201
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97
0
1.1
97
0
1.1
97
0
1.1
94.8
0
1.1
94.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretogranin V
VGNC:14731
453292
Macaque
secretogranin V
694088
Mouse
MGI:98289
20394
Rat
RGD:3669
25719
Dog
secretogranin V
VGNC:45907
478249
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretogranin V
Macaque
secretogranin V
Mouse
Rat
Dog
secretogranin V
Publication Statistics
PubMed Score 36.99
PubMed score by year
PubTator Score 89.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title