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Tbio
SCG2
Secretogranin-2

Protein Summary
Description
Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305409
  • ENSP00000304133
  • ENSG00000171951

Symbol
  • CHGC
  • SN
  • CHGC
  • EM66
  • SgII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
biological process
0.74
disease perturbation
0.74
small molecule perturbation
0.67
disease
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.84   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.84   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (171)
CHGB
Tbio
Novelty:  0.00484507
Score:  0.992
Data Source:  STRINGDB
SCG3
Tbio
Novelty:  0.02153066
Score:  0.987
Data Source:  STRINGDB
VGF
Tbio
Novelty:  0.00521876
Score:  0.97
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.96
Data Source:  STRINGDB
MEN1
Tchem
Novelty:  0.00059287
Score:  0.941
Data Source:  STRINGDB
TGOLN2
Tbio
Novelty:  0.005107
Score:  0.923
Data Source:  STRINGDB
IGFBP1
Tchem
Novelty:  0.0006975
Score:  0.919
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.914
Data Source:  STRINGDB
IGFBP5
Tchem
Novelty:  0.0025185
Score:  0.913
Data Source:  STRINGDB
SPARCL1
Tbio
Novelty:  0.01077806
Score:  0.911
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
2
1
2
71.7
sodium measurement
1
1
1
13.1
airway wall thickness measurement
1
1
1
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
2
71.7
sodium measurement
1
13.1
airway wall thickness measurement
1
7.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretogranin II
VGNC:2808
459977
Macaque
secretogranin II
706499
Mouse
MGI:103033
20254
Rat
RGD:3626
24765
Dog
secretogranin II
VGNC:45905
488550
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretogranin II
Macaque
secretogranin II
Mouse
Rat
Dog
secretogranin II
Publication Statistics
PubMed Score 324.84
PubMed score by year
PubTator Score 159.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title