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Tbio
SCFD1
Sec1 family domain-containing protein 1

Protein Summary
Description
Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396629
  • ENSP00000379870
  • ENSG00000092108
  • ENST00000458591
  • ENSP00000390783
  • ENST00000544052
  • ENSP00000443010

Symbol
  • C14orf163
  • KIAA0917
  • STXBP1L2
  • SLY1
  • RA410
  • SLY1P
  • STXBP1L2
  • C14orf163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.86
trait
0.86
histone modification site profile
0.81
virus perturbation
0.79
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (178)
STX5
Tbio
Novelty:  0.00964918
p_int:  0.987697116
p_ni:  0.012302884
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.974323587
p_ni:  0.025676413
Score:  0.88
Data Source:  BioPlex,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.880484136
p_ni:  0.119515864
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
USE1
Tbio
Novelty:  0.00904756
p_int:  0.786206202
p_ni:  0.213793798
Score:  0.956
Data Source:  BioPlex,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.761864099
p_ni:  0.238135901
Score:  0.985
Data Source:  BioPlex,STRINGDB
GOSR2
Tbio
Novelty:  0.02447711
Score:  0.997
Data Source:  Reactome,STRINGDB
USO1
Tbio
Novelty:  0.02066669
Score:  0.997
Data Source:  Reactome,STRINGDB
NSF
Tbio
Family:  Enzyme
Novelty:  0.00173489
Score:  0.997
Data Source:  Reactome,STRINGDB
BET1
Tdark
Novelty:  0.01791164
Score:  0.997
Data Source:  Reactome,STRINGDB
YKT6
Tbio
Novelty:  0.01591063
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
59.4
mean corpuscular volume
1
1
1
28.1
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
59.4
mean corpuscular volume
1
28.1
0
1.1
17.8
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sec1 family domain containing 1
VGNC:3317
452835
Macaque
sec1 family domain containing 1
716756
Mouse
MGI:1924233
76983
Rat
RGD:619828
54350
Dog
sec1 family domain containing 1
VGNC:45903
480281
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sec1 family domain containing 1
Macaque
sec1 family domain containing 1
Mouse
Rat
Dog
sec1 family domain containing 1
Publication Statistics
PubMed Score 36.57
PubMed score by year
PubTator Score 11.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title