You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SCEL
Sciellin

Protein Summary
Description
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349847
  • ENSP00000302579
  • ENSG00000136155
  • ENST00000377246
  • ENSP00000366454
  • ENST00000535157
  • ENSP00000437895
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
kinase perturbation
0.76
tissue sample
0.65
PubMedID
0.64
transcription factor
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999994325
p_ni:  0.000005464
p_wrong:  2.11e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
HSF2
Tbio
Family:  TF
Novelty:  0.06458223
p_int:  0.999986469
p_ni:  0.000005265
p_wrong:  0.000008266
Data Source:  BioPlex
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.81124658
p_ni:  0.18875342
Score:  0.242
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
Score:  0.713
Data Source:  STRINGDB
SULF1
Tbio
Family:  Enzyme
Novelty:  0.00992209
Score:  0.712
Data Source:  STRINGDB
SYNPO
Tbio
Novelty:  0.00461054
Score:  0.711
Data Source:  STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.711
Data Source:  STRINGDB
SPRR2B
Tdark
Novelty:  0.36342019
Score:  0.708
Data Source:  STRINGDB
EVPL
Tbio
Novelty:  0.00274279
Score:  0.692
Data Source:  STRINGDB
ACTN4
Tbio
Novelty:  0.0040236
Score:  0.69
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sciellin
VGNC:13138
737187
Macaque
sciellin
696980
Mouse
MGI:1891228
64929
Rat
RGD:1305102
361086
Dog
sciellin
VGNC:45902
100683601
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sciellin
Macaque
sciellin
Mouse
Rat
Dog
sciellin
Publication Statistics
PubMed Score 31.52
PubMed score by year
PubTator Score 13.52
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title