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Tchem
SCD5
Stearoyl-CoA desaturase 5

Protein Summary
Description
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273908
  • ENSP00000273908
  • ENSG00000145284
  • ENST00000319540
  • ENSP00000316329

Symbol
  • ACOD4
  • SCD2
  • SCD4
  • SCD2
  • SCD4
  • ACOD4
  • FADS4
  • HSCD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
small molecule perturbation
0.84
PubMedID
0.81
microRNA
0.79
cell type or tissue
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.23   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.23   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (87)
ACOT1
Tbio
Family:  Enzyme
Novelty:  0.01211801
Score:  0.918
Data Source:  STRINGDB
ACOT2
Tbio
Family:  Enzyme
Novelty:  0.03086222
Score:  0.911
Data Source:  STRINGDB
ACOT4
Tbio
Family:  Enzyme
Novelty:  0.13441184
Score:  0.902
Data Source:  STRINGDB
ITIH4
Tbio
Novelty:  0.00032471
Score:  0.838
Data Source:  STRINGDB
SCD
Tchem
Family:  Enzyme
Novelty:  0.00063325
Score:  0.809
Data Source:  STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.806
Data Source:  STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
Score:  0.767
Data Source:  STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.731
Data Source:  STRINGDB
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.725
Data Source:  STRINGDB
ERVW-1
Tbio
Novelty:  0.00038992
Score:  0.71
Data Source:  STRINGDB
Pathways (10)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
6
6
6
95.7
lymphocyte count
7
6
7
95.4
leukocyte count
5
3
5
86.1
type 2 diabetes mellitus
4
3
3
1
81.6
eosinophil count
4
2
4
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
6
95.7
lymphocyte count
7
95.4
leukocyte count
5
86.1
type 2 diabetes mellitus
3
1
81.6
eosinophil count
4
79.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stearoyl-CoA desaturase 5
VGNC:2005
461211
Macaque
stearoyl-CoA desaturase 5
694079
Dog
stearoyl-CoA desaturase 5
VGNC:45901
487831
Horse
stearoyl-CoA desaturase 5
VGNC:51306
100060968
Cow
stearoyl-CoA desaturase 5
VGNC:34328
617419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stearoyl-CoA desaturase 5
Macaque
stearoyl-CoA desaturase 5
Dog
stearoyl-CoA desaturase 5
Horse
stearoyl-CoA desaturase 5
Cow
stearoyl-CoA desaturase 5
Publication Statistics
PubMed Score 306.23
PubMed score by year
PubTator Score 104.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title