Protein Summary
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturas ...more
- ENST00000370355
- ENSP00000359380
- ENSG00000099194
- SCD1
- FADS5
- SCDOS
- hSCD1
- MSTP008
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.99 | ||
gene perturbation | 0.98 | ||
small molecule perturbation | 0.93 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1584.56 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 271 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1584.56 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 271 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 537
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (537)
Protein-Protein Interactions (195)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (21)
Reactome (7)
KEGG (5)
PathwayCommons (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Fatty acyl-CoA biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Fatty acid metabolism | ||||
Fatty acyl-CoA biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (6)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 2 | 4 | 89.2 | |||||
blood metabolite measurement | 3 | 1 | 6 | 87.4 | |||||
metabolite measurement | 1 | 1 | 1 | 85.2 | |||||
heel bone mineral density | 3 | 1 | 4 | 82.7 | |||||
alkaline phosphatase measurement | 2 | 1 | 1 | 8.2 | 81.4 | ||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 89.2 | |||||
blood metabolite measurement | 6 | 87.4 | |||||
metabolite measurement | 1 | 85.2 | |||||
heel bone mineral density | 4 | 82.7 | |||||
alkaline phosphatase measurement | 1 | 8.2 | 81.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | stearoyl-CoA desaturase | VGNC:10458 | 450676 | |||||
Macaque | stearoyl-CoA desaturase | 710155 | ||||||
Mouse | MGI:98240 | 20250 | ||||||
Rat | RGD:621177 | 83792 | ||||||
Dog | stearoyl-CoA desaturase | VGNC:45900 | 486839 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | stearoyl-CoA desaturase | |||||
Macaque | stearoyl-CoA desaturase | |||||
Mouse | ||||||
Rat | ||||||
Dog | stearoyl-CoA desaturase | |||||
Publication Statistics
PubMed Score 1584.56
PubMed score by year
PubTator Score 456.18
PubTator score by year
Related Publications
Text Mined References (123)
GeneRif Annotations (98)
Items per page:
0 of 0
PMID | Year | Title |
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