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Tchem
SCARB1
Scavenger receptor class B member 1

Protein Summary
Description
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694). The protein encoded ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261693
  • ENSP00000261693
  • ENSG00000073060
  • ENST00000339570
  • ENSP00000343795
  • ENST00000415380
  • ENSP00000414979

Symbol
  • CD36L1
  • CLA1
  • CLA1
  • SRB1
  • CLA-1
  • SR-BI
  • CD36L1
  • HDLQTL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
cellular component
0.99
biological term
0.98
molecular function
0.96
disease
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2424.62   (req: < 5)
Gene RIFs: 242   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2424.62   (req: >= 5)
Gene RIFs: 242   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (148)
BTNL8
Tdark
Novelty:  0.40339869
p_int:  0.998929543
p_ni:  0.001070457
Data Source:  BioPlex
PDZK1P1
Tdark
p_int:  0.995777159
p_ni:  0.004222841
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.994717173
p_ni:  0.005282825
p_wrong:  2e-9
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.979711363
p_ni:  0.020288637
Score:  0.158
Data Source:  BioPlex,STRINGDB
CLDN7
Tbio
Novelty:  0.00722366
p_int:  0.972977433
p_ni:  0.027022567
Score:  0.714
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.96798853
p_ni:  0.03201147
Data Source:  BioPlex
SFTPC
Tbio
Novelty:  0.00154396
p_int:  0.967174807
p_ni:  0.032825193
Score:  0.197
Data Source:  BioPlex,STRINGDB
EDDM3A
Tdark
Novelty:  0.05607223
p_int:  0.943423891
p_ni:  0.056576109
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.911801087
p_ni:  0.088198905
p_wrong:  8e-9
Score:  0.266
Data Source:  BioPlex,STRINGDB
KDELR2
Tbio
Novelty:  0.12002642
p_int:  0.908616639
p_ni:  0.091383361
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
HDL clearance
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Scavenging by Class B Receptors
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
HDL clearance
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Scavenging by Class B Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (50)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
25
38
99.5
apolipoprotein A 1 measurement
2
8
8
98.6
sleep duration
2
7
8
91.2
5
4
5
1.1
89.7
low density lipoprotein cholesterol measurement
4
4
4
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
38
99.5
apolipoprotein A 1 measurement
8
98.6
sleep duration
8
91.2
5
1.1
89.7
low density lipoprotein cholesterol measurement
4
88
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class B member 1
VGNC:8529
452359
Macaque
scavenger receptor class B member 1
712726
Mouse
MGI:893578
20778
Rat
RGD:2302
25073
Dog
scavenger receptor class B member 1
VGNC:45898
486241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class B member 1
Macaque
scavenger receptor class B member 1
Mouse
Rat
Dog
scavenger receptor class B member 1
Publication Statistics
PubMed Score 2424.62
PubMed score by year
PubTator Score 581.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title