You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SCARA5
Scavenger receptor class A member 5

Protein Summary
Description
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354914
  • ENSP00000346990
  • ENSG00000168079
  • ENST00000380385
  • ENSP00000369746
  • ENST00000518030
  • ENSP00000430713
  • ENST00000524352
  • ENSP00000428663

Symbol
  • Tesr
  • NET33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.58
biological process
0.56
microRNA
0.53
small molecule perturbation
0.53
disease
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0