SCARA5
Scavenger receptor class A member 5
Protein Summary
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
- ENST00000354914
- ENSP00000346990
- ENSG00000168079
- ENST00000380385
- ENSP00000369746
- ENST00000518030
- ENSP00000430713
- ENST00000524352
- ENSP00000428663
- Tesr
- NET33
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.58 | ||
biological process | 0.56 | ||
microRNA | 0.53 | ||
small molecule perturbation | 0.53 | ||
disease | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 176 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 176 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0