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Tbio
SCAMP4
Secretory carrier-associated membrane protein 4

Protein Summary
Description
Probably involved in membrane protein trafficking. Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316097
  • ENSP00000316007
  • ENSG00000227500
  • ENST00000409472
  • ENSP00000386865
  • ENST00000621748
  • ENSP00000479083

Symbol
  • SCAMP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.76
interacting protein
0.71
histone modification site profile
0.67
virus perturbation
0.64
tissue sample
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.998087568
p_ni:  0.001906412
p_wrong:  0.00000602
Score:  0.38
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.976479677
p_ni:  0.023199915
p_wrong:  0.000320408
Score:  0.406
Data Source:  BioPlex,STRINGDB
ABHD17A
Tbio
Family:  Enzyme
Novelty:  0.26144756
Score:  0.737
Data Source:  STRINGDB
DUS3L
Tbio
Family:  Enzyme
Novelty:  0.24952542
Score:  0.685
Data Source:  STRINGDB
REXO1
Tdark
Family:  Enzyme
Novelty:  0.23817911
Score:  0.674
Data Source:  STRINGDB
SH3GL1
Tbio
Novelty:  0.02379336
Score:  0.595
Data Source:  STRINGDB
NMRK2
Tbio
Family:  Kinase
Novelty:  0.11112212
Score:  0.543
Data Source:  STRINGDB
ZBTB21
Tbio
Family:  TF
Novelty:  0.16032292
Score:  0.54
Data Source:  STRINGDB
NAA50
Tchem
Family:  Enzyme
Novelty:  0.01843508
Score:  0.536
Data Source:  STRINGDB
OAZ1
Tbio
Family:  Enzyme
Novelty:  0.0224953
Score:  0.517
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
2
2
86.7
mean reticulocyte volume
1
2
2
86.4
body mass index
4
4
5
85.3
mean corpuscular hemoglobin concentration
1
1
1
76.5
reticulocyte measurement
3
1
3
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
86.7
mean reticulocyte volume
2
86.4
body mass index
5
85.3
mean corpuscular hemoglobin concentration
1
76.5
reticulocyte measurement
3
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretory carrier membrane protein 4
VGNC:13166
743595
Macaque
secretory carrier membrane protein 4
709219
Mouse
MGI:1928947
56214
Rat
RGD:68354
65170
Dog
secretory carrier membrane protein 4
VGNC:45892
612221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretory carrier membrane protein 4
Macaque
secretory carrier membrane protein 4
Mouse
Rat
Dog
secretory carrier membrane protein 4
Publication Statistics
PubMed Score 5.87
PubMed score by year
PubTator Score 0.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title