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Tbio
SCAMP3
Secretory carrier-associated membrane protein 3

Protein Summary
Description
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302631
  • ENSP00000307275
  • ENSG00000116521
  • ENST00000355379
  • ENSP00000347540
  • ENST00000570831
  • ENSP00000461521
  • ENSG00000263290
  • ENST00000573013
  • ENSP00000458542

Symbol
  • C1orf3
  • PROPIN1
  • C1orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.97
kinase perturbation
0.84
transcription factor binding site profile
0.82
histone modification site profile
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.94   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.94   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.993001846
p_ni:  0.006998154
Data Source:  BioPlex
SUGP1
Tbio
Novelty:  0.00434166
Score:  0.818
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.795
Data Source:  STRINGDB
MPLKIP
Tbio
Family:  Enzyme
Novelty:  0.01661924
Score:  0.789
Data Source:  STRINGDB
MTX1
Tbio
Novelty:  0.02350764
Score:  0.703
Data Source:  STRINGDB
PLEKHO1
Tbio
Novelty:  0.01658553
Score:  0.692
Data Source:  STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.686
Data Source:  STRINGDB
GBA
Tclin
Family:  Enzyme
Novelty:  0.00051172
Score:  0.567
Data Source:  STRINGDB
NUP210L
Tdark
Novelty:  0.38513321
Score:  0.565
Data Source:  STRINGDB
STAM
Tbio
Novelty:  0.0332731
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (86)
Items per page:
1 – 5 of 86
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
5
9
98.3
urate measurement
6
5
9
98.3
serum urea measurement
2
3
3
95.4
serum urea measurement
2
3
3
95.4
reticulocyte measurement
3
2
4
93.8
Items per page:
1 – 5 of 86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
98.3
urate measurement
9
98.3
serum urea measurement
3
95.4
serum urea measurement
3
95.4
reticulocyte measurement
4
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretory carrier membrane protein 3
VGNC:10994
457363
Macaque
secretory carrier membrane protein 3
106992772
Mouse
MGI:1346346
24045
Horse
secretory carrier membrane protein 3
VGNC:22710
100057345
Cow
secretory carrier membrane protein 3
VGNC:34317
539670
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretory carrier membrane protein 3
Macaque
secretory carrier membrane protein 3
Mouse
Horse
secretory carrier membrane protein 3
Cow
secretory carrier membrane protein 3
Publication Statistics
PubMed Score 21.94
PubMed score by year
PubTator Score 7.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title