Tbio SCAI Protein SCAI

Protein Summary

Description

Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q8N9R8
• Q3SXZ1
• Q3SXZ2
• Q5T163
• Q8N1I4

Gene Name

• SCAI

Ensembl ID

• ENST00000336505
• ENSP00000336756
• ENSG00000173611
• ENST00000373549
• ENSP00000362650

Symbol

• C9orf126
• NET40
• C9orf126

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.8
trait	0.75
transcription factor binding site profile	0.74
virus perturbation	0.72
histone modification site profile	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1314.95   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1314.95   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0