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Tbio
SC5D
Lathosterol oxidase

Protein Summary
Description
Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264027
  • ENSP00000264027
  • ENSG00000109929
  • ENST00000392789
  • ENSP00000376539

Symbol
  • SC5DL
  • ERG3
  • S5DES
  • SC5DL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.81
small molecule perturbation
0.73
transcription factor binding site profile
0.69
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.99971428
p_ni:  0.000283038
p_wrong:  0.000002682
Data Source:  BioPlex
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
p_int:  0.99649332
p_ni:  0.00326574
p_wrong:  0.00024094
Score:  0.522
Data Source:  BioPlex,STRINGDB
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.9795132
p_ni:  0.019472068
p_wrong:  0.001014731
Score:  0.203
Data Source:  BioPlex,STRINGDB
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
p_int:  0.966328377
p_ni:  0.03260064
p_wrong:  0.001070983
Score:  0.153
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.941368865
p_ni:  0.001858353
p_wrong:  0.056772781
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.892179504
p_ni:  0.106246568
p_wrong:  0.001573928
Score:  0.177
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.881247346
p_ni:  0.116482585
p_wrong:  0.002270069
Score:  0.228
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.865672941
p_ni:  0.005502911
p_wrong:  0.128824148
Data Source:  BioPlex
RXFP4
Tchem
Family:  GPCR
Novelty:  0.05054041
p_int:  0.84360602
p_ni:  0.155857625
p_wrong:  0.000536355
Score:  0.269
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.797193413
p_ni:  0.002538658
p_wrong:  0.200267929
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Cholesterol biosynthesis via desmosterol
Reactome
Cholesterol biosynthesis via lathosterol
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Cholesterol biosynthesis via desmosterol
Cholesterol biosynthesis via lathosterol
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1353611
235293
Rat
RGD:620775
114100
Dog
sterol-C5-desaturase
VGNC:45887
610411
Horse
sterol-C5-desaturase
VGNC:22708
100063543
Cow
sterol-C5-desaturase
VGNC:34312
525154
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
sterol-C5-desaturase
Horse
sterol-C5-desaturase
Cow
sterol-C5-desaturase
Publication Statistics
PubMed Score 40.91
PubMed score by year
PubTator Score 17.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title