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Tbio
SBF1
Myotubularin-related protein 5

Protein Summary
Description
Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. According to PubMed:20937701, may function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth di ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348911
  • ENSP00000252027
  • ENSG00000100241
  • ENST00000380817
  • ENSP00000370196

Symbol
  • MTMR5
  • MTMR5
  • CMT4B3
  • DENND7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell type or tissue
0.88
tissue sample
0.72
kinase perturbation
0.71
microRNA
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.14   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.14   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.999981868
p_ni:  0.00001813
p_wrong:  2e-9
Score:  0.36
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.999217538
p_ni:  0.000782462
Data Source:  BioPlex
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.997342104
p_ni:  0.002657896
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.996752917
p_ni:  0.003247082
p_wrong:  1e-9
Data Source:  BioPlex
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
p_int:  0.996085568
p_ni:  0.003914431
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
GFOD1
Tdark
Family:  Enzyme
Novelty:  0.35031766
p_int:  0.99370299
p_ni:  0.00629701
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.993526173
p_ni:  0.006473826
p_wrong:  1e-9
Data Source:  BioPlex
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.993165972
p_ni:  0.006834028
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.992492369
p_ni:  0.007507631
Data Source:  BioPlex
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.990640372
p_ni:  0.009359628
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
7
8
99
mean reticulocyte volume
1
4
4
97.6
red blood cell distribution width
4
4
4
95.6
mean corpuscular hemoglobin
3
3
3
94.6
mean corpuscular hemoglobin concentration
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
8
99
mean reticulocyte volume
4
97.6
red blood cell distribution width
4
95.6
mean corpuscular hemoglobin
3
94.6
mean corpuscular hemoglobin concentration
2
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET binding factor 1
VGNC:6016
470250
Macaque
SET binding factor 1
715955
Mouse
MGI:1925230
77980
Rat
RGD:1307090
300147
Horse
SET binding factor 1
VGNC:22705
100056491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET binding factor 1
Macaque
SET binding factor 1
Mouse
Rat
Horse
SET binding factor 1
Publication Statistics
PubMed Score 56.14
PubMed score by year
PubTator Score 20.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title