Tbio SBDS Ribosome maturation protein SBDS

Protein Summary

Description

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9Y3A5
• A8K0P4
• Q96FX0
• Q9NV53

Gene Name

• SBDS

Ensembl ID

• ENST00000246868
• ENSP00000246868
• ENSG00000126524

Symbol

• SDS
• SWDS
• CGI-97

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
virus perturbation	0.9
histone modification site profile	0.83
transcription factor binding site profile	0.75
biological process	0.66

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ribosome Maturation Protein Sbds

Protein / Nucleic Acid Binding / Nuclease / Ribosome Maturation Protein Sbds

DTO Classes

Protein / Enzyme / Nuclease / Ribosome Maturation Protein Sbds

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.71   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.71   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0