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Tbio
SBDS
Ribosome maturation protein SBDS

Protein Summary
Description
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a cl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246868
  • ENSP00000246868
  • ENSG00000126524

Symbol
  • SDS
  • SWDS
  • CGI-97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
virus perturbation
0.9
histone modification site profile
0.83
transcription factor binding site profile
0.75
biological process
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.09   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.09   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
FGB
Tbio
Novelty:  0.00437751
p_int:  0.99999258
p_ni:  0.000007416
p_wrong:  4e-9
Data Source:  BioPlex
EGLN3
Tclin
Novelty:  0.00643992
p_int:  0.999984597
p_ni:  0.000015403
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999976238
p_ni:  0.000023683
p_wrong:  8e-8
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.999968115
p_ni:  0.000030647
p_wrong:  0.000001238
Data Source:  BioPlex
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.999728213
p_ni:  0.000124322
p_wrong:  0.000147464
Score:  0.179
Data Source:  BioPlex,STRINGDB
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.998859838
p_ni:  0.000797281
p_wrong:  0.000342882
Score:  0.185
Data Source:  BioPlex,STRINGDB
INTU
Tbio
Novelty:  0.02714388
p_int:  0.895357822
p_ni:  0.001016341
p_wrong:  0.103625837
Score:  0.159
Data Source:  BioPlex,STRINGDB
EFL1
Tbio
Novelty:  0.1323879
Score:  0.992
Data Source:  STRINGDB
EIF6
Tbio
Novelty:  0.01271382
Score:  0.895
Data Source:  STRINGDB
RPUSD2
Tdark
Family:  Enzyme
Novelty:  1.41606982
Score:  0.864
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SBDS, ribosome maturation factor
VGNC:8747
463942
Mouse
MGI:1913961
66711
Rat
RGD:1311043
288615
Dog
SBDS, ribosome maturation factor
VGNC:45881
607017
Horse
SBDS, ribosome maturation factor
VGNC:22704
100060921
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SBDS, ribosome maturation factor
Mouse
Rat
Dog
SBDS, ribosome maturation factor
Horse
SBDS, ribosome maturation factor
Publication Statistics
PubMed Score 129.09
PubMed score by year
PubTator Score 111.71
PubTator score by year
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Related Publications
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PMID
Year
Title