You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SAV1
Protein salvador homolog 1

Protein Summary
Description
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the tra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324679
  • ENSP00000324729
  • ENSG00000151748

Symbol
  • WW45
  • SAV
  • WW45
  • WWP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.77
virus perturbation
0.76
transcription factor binding site profile
0.69
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.61   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.61   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
p_int:  0.999988108
p_ni:  0.000011892
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.999982527
p_ni:  0.000017473
Data Source:  BioPlex
ZNF554
Tdark
Family:  TF
Novelty:  1.57478216
p_int:  0.999982276
p_ni:  0.000017724
Data Source:  BioPlex
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
p_int:  0.99981225
p_ni:  0.00018775
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
ADCYAP1
Tbio
Family:  Enzyme
Novelty:  0.00080219
p_int:  0.999803309
p_ni:  0.000196655
p_wrong:  3.6e-8
Score:  0.663
Data Source:  BioPlex,STRINGDB
ZNF420
Tbio
Family:  TF
Novelty:  0.20022795
p_int:  0.999790755
p_ni:  0.000209245
Score:  0.747
Data Source:  BioPlex,STRINGDB
ZNF695
Tdark
Family:  TF
Novelty:  0.37164664
p_int:  0.999479899
p_ni:  0.000520097
p_wrong:  4e-9
Score:  0.552
Data Source:  BioPlex,STRINGDB
ZIM2
Tbio
Family:  TF
Novelty:  0.08135678
p_int:  0.998928438
p_ni:  0.001071558
p_wrong:  4e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.996911801
p_ni:  0.003088199
Data Source:  BioPlex
ZNF133
Tbio
Family:  TF
Novelty:  0.20117958
p_int:  0.996361192
p_ni:  0.003638808
Score:  0.665
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
5
5
98.2
Dupuytren Contracture
1
1
0
1.2
68.6
platelet count
1
2
2
68.4
serum alanine aminotransferase measurement
1
1
0
6.9
52.4
balding measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
98.2
Dupuytren Contracture
0
1.2
68.6
platelet count
2
68.4
serum alanine aminotransferase measurement
0
6.9
52.4
balding measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
salvador family WW domain containing protein 1
VGNC:12527
452899
Macaque
salvador family WW domain containing protein 1
706424
Mouse
MGI:1927144
64010
Rat
RGD:1307253
299116
Dog
salvador family WW domain containing protein 1
VGNC:45877
480319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
salvador family WW domain containing protein 1
Macaque
salvador family WW domain containing protein 1
Mouse
Rat
Dog
salvador family WW domain containing protein 1
Publication Statistics
PubMed Score 101.61
PubMed score by year
PubTator Score 40.35
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title